A novel triterpene saponin (1) was isolated from an ethanol extract of the root bark of Aralia dasyphylla. Its structure was elucidated as 3-O-[β-D-glucopyranosyl(1→3)-β-D-galactopyranosyl(1→2)]-β-D-glucuronopyranosyl-oleanolic acid-28-O-β-D-glucopyranoside, according to spectral and chemical evidence. Compound 1 showed significant cytotoxic activity against KB and Hela-S3 cells.
glycoside, cytotoxic activity, triterpene saponin, Aralia dasyphylla
NCBI PubMed ID: 10425135Publication DOI: 10.1021/np9805185Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence:
Institutions: School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, HPLC, alkaline hydrolysis, optical rotation measurement, cytotoxicity assay, HMBC, HMQC, COSY, NOESY, HOHAHA, HCl hydrolysis
Found