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Structure type: oligomer
Trivial name: pseudoginsenoside F11, 24(R)-pseudoginsenoside F11
Compound class: saponin glycoside, glycoside
Contained glycoepitopes: IEDB_136105,IEDB_142488,IEDB_144144,IEDB_146664,IEDB_225177,IEDB_885823,IEDB_983931,SB_192

• Article ID: 11706
  Li Z, Guo YY, Wu CF, Li X, Wang JH "Protective effects of pseudoginsenoside F11 on scopolamine-induced memory impairment in mice and rats" - Journal of Pharmacy and Pharmacology 51(4) (1999) 435-440
  

  This study assessed the effects of pseudoginsenoside F11, a component of Panax quinquefolium L., on scopolamine-impaired memory performance in mice and rats. In the one-trial step-down and step-through passive avoidance tests, although pseudoginsenoside F11 used alone did not affect passive avoidance behaviour in naive mice, the latency of avoidance shortened by intraperitoneal scopolamine (2 mg kg-1) was prolonged after intragastric administration of pseudoginsenoside F11 (2 or 4 mg kg-1, for five days) in both test systems in mice. In the water-maze test, in mice, the time taken to locate the platform after administration of pseudoginsenoside F11 was shorter than that after administration of scopolamine (1 mg kg-1, i.p.). In the two-way active avoidance response test, the latency of avoidance was significantly shorter for the pseudoginsenoside F11- (1.2 or 2.4 mg kg-1, i.g. for five days) and scopolamine-treated group than for the group of rats given scopolamine only (2 mg kg-1, i.p.). The percentage avoidance was also reduced after intraperitoneal injection of scopolamine, but was reversed by administration of pseudoginsenoside F11. These results suggest that pseudoginsenoside F11 antagonized the memory dysfunction induced by scopolamine. However, the mechanism of the memory facilitative action of pseudoginsenoside F11 merits further elucidation.

  Panax quinquefolium, pseudoginsenoside F11, memory dysfunction

  NCBI PubMed ID: 10385216
  Publication DOI: 10.1211/0022357991772484
  Journal NLM ID: 0376363
  Publisher: London: Pharmaceutical Society of Great Britain; West Sussex: Wiley
  Institutions: Department of Pharmacology of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110015, China, Department of Chemistry for Nature Products, Shenyang Pharmaceutical University, Shenyang 110015, China
  Methods: statistical analysis, memory dysfunction assay
  
   
  
  Panax quinquefolius
  CSDB ID 62628 (all data & tools)
• Article ID: 12367
  Li W, Gu C, Zhang H, Awang DVC, Fitzloff JF, Fong HHS, van Breemen RB "Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng)" - Analytical Chemistry 72(21) (2000) 5417-5422
  

  A liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed to distinguish Asian ginseng (Panax ginseng C. A. Meyer) and North American ginseng (Panax quinquefolius L.). The method is based on the baseline chromatographic separation of ginsenoside Rf and 24(R)-pseudoginsenoside F11, two potential chemical markers present in ginseng root methanolic extracts, and their unambiguous on-line identification using tandem mass spectrometry. Consistent with the literature, 24(R)-pseudoginsenoside F11 was detected in abundance in North American ginseng roots in excess of 0.1% (w/w) of the dried root. In contrast to some reports, 24(R)-pseudoginsenoside F11 was also identified in Asian ginseng roots at trace levels using LC-MS-MS but at less than 0.0001% (w/w). Besides showing identical tandem mass spectra to authentic 24(R)-pseudoginsenoside F11, the corresponding compound in Asian ginseng root coeluted with standard under different HPLC conditions, thus confirming this compound as 24(R)-pseudoginsenoside F11. Another ginsenoside often used to distinguish Asian and North American ginseng, ginsenoside Rf, was found in abundance in Asian ginseng roots at more than 0.021% (w/w). In Asian ginseng roots, the ratio of ginsenoside Rf to 24(R)-pseudoginsenoside F11 exceeded 700:1. The limit of detection of ginsenoside Rf or 24(R)-pseudoginsenoside F11 was 120 pg injected on-column, and the limit of quantification was 240 pg on-column. In summary, LC-MS-MS analysis of ginseng products for the presence and ratio of ginsenoside Rf and 24(R)-pseudoginsenoside F11 may be used for the unambiguous identification of Asian and North American ginsengs.

  Panax ginseng, HPLC-MS/MS, Panax quinquefolius

  NCBI PubMed ID: 11080895
  Publication DOI: 10.1021/ac000650l
  Journal NLM ID: 0370536
  Correspondence: breemen@uic.edu
  Institutions: Program for Collaborative Research in the Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL, USA, Functional Foods for Health Core Analytical Laboratory, University of Illinois at Chicago, Chicago, IL, USA, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA, MediPlant Consulting Services, White Rock, Canada
  
   
  
  Panax ginseng, Panax quinquefolius
  CSDB ID 66325 (all data & tools)