CSDB: Search results

Two flavone glycosides, hispidulin 4'-O-β-D-glucopyranoside and nepetin 4'-O-β-D-glucopyranoside, were isolated from the leaves of Cirsium oligophyllum and identified on the basis of their 1H and 13C NMR, FAB-MS, UV spectra and characterization of their hydrolysates; hispidulin 7,4'-glycoside, vicenin-2, hispidulin and nepetin were also isolated.

FAB-MS, compositae, Cirsium oligophyllum, flavone glycosides, hispidulin 4′-glucoside, nepetin 4′-glucoside, 1H and 13C NMR spectroscopy

Publication DOI: 10.1016/S0031-9422(99)00178-8
Journal NLM ID: 0151434
Publisher: Elsevier
Correspondence: Iwashina T
Institutions: Tsukuba Botanical Garden, National Science Museum, 4-1-1, Amakubo, Tsukuba, Ibaraki 305-0005, Japan, Tsukuba Research Laboratory, Nippon Oil and Fats Co. Ltd, 5-10, Tokodai, Tsukuba, Ibaraki 300-2635, Japan, 6-49-8, Nishi-nippori, Arakawa-ku, Tokyo 116-0013, Japan
Methods: 13C NMR, 1H NMR, FAB-MS, acid hydrolysis, UV, PC

Rosemary and sage are common spices used in food. In our recent search of cancer chemopreventive agents from spices, the alcohol extracts of rosemary and sage showed strong antumorigenic activities. Rosemary and sage extracts contain active antioxidative factors such as phenolic diterpenes, flavonoids and phenolic acids. Here we discuss chromatographic methods used to separate and purify compounds from these spices and MS and NMR spectrometry to identify the isolated compounds. Several new compounds isolated from sage were determined to be 6-O-caffeoyl-β-D-fructofuranosyl-(2→1)-β-glucopyranoside, 1-O-caffeoyl-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside, 1-O-p-hydroxybenzoyl-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside, 1-O-(3-methyl-2,3,4-trihydroxybutyl)-6-O-feruloyl-β-D-glucopyranoside, 4-hydroxyacetophenone 4-O-[5-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-D-apiofuranosyl]-(1→2)-β-D-glucopyranoside and 1-O-[2-hydroxy-5-(2-hydroxyethyl)phenyl]-6-O-trans-caffeoyl-β-D-glucopyranoside.

Antioxidant activity, phenolic glycosides, flavonoids, rosemary, sage

NCBI PubMed ID: 11237177
Publication DOI: 10.1002/biof.5520130126
Journal NLM ID: 8807441
Publisher: Oxford; Washington, DC: IRL Press, International Union of Biochemistry
Correspondence: Ho CT
Institutions: Department of Food Science, Rutgers University, New Brunswick, NJ, USA, Department of Food Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan, Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, USA

Three new acylated flavonol glycosides, patuletin 7-O-(6‘‘-isobutyryl)glucoside (1), patuletin 7-O-[6‘‘-(2-methylbutyryl)]glucoside (2), and patuletin 7-O-(6‘‘-isovaleryl)glucoside (3), were isolated from the n-BuOH extract of Inula britannica flowers by bioassay-guided fractionation, together with other known flavonoids. The structures were elucidated by 1D and 2D NMR, FABMS, and other spectral analyses. The eight flavonoids, including new compounds (1−3), patulitrin (7), nepitrin (8), axillarin (10), patuletin (11), and luteolin (12), showed profound antioxidant activity in DPPH assay and cytochrome-c reduction assay using HL-60 cell culture system.

Antioxidant activity, flavonol glycosides, Inula britannica, patuletin

NCBI PubMed ID: 10650074
Publication DOI: 10.1021/np990271r
Journal NLM ID: 7906882
Publisher: American Society of Pharmacognosy
Correspondence: Kim J
Institutions: College of Pharmacy, Seoul National University, Seoul, South Korea
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, acid hydrolysis, HPLC, alkaline hydrolysis, extraction, CI-MS, HR-ESI-MS, evaporation, centrifugation