Two new acylated flavone glucosides, skullcapflavone I 2'-O-β-D-(3-E-cinnamoyl)glucopyranoside and skullcapflavone I 2'-O-β-D-(2-E-cinnamoyl)glucopyranoside, together with skullcapflavone I 2'-O-β-D-glucopyranoside and andrographidine C have been isolated from the whole plant of Andrographis serpyllifolia. Structural elucidation of the glycosides was achieved by various NMR techniques including 1H-1H COSY, HMQC, HMBC and ROESY experiments, FAB-mass spectrometry, acid hydrolysis and saponification.
Acanthaceae, whole plant, Andrographis serpyllifolia, acylated flavone glucosides, skullcapflavone I 2′-(3″-E-cinnamoyl)glucoside, skullcapflavone I 2′-(2″-E-cinnamoyl)glucoside
Publication DOI: 10.1016/S0031-9422(99)00113-2Journal NLM ID: 0151434Publisher: Elsevier
Institutions: Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, 517 502, India, Laboratoire de Chimie des Substances Naturelles, URA 401 CNRS, Museum National d’Histoire Naturelle, 63 rue Buffon, 75005, Paris, France
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, alkaline hydrolysis, UV, optical rotation measurement, ROESY, PC, HMBC, HMQC, HR-FAB-MS, HCl hydrolysis
Found