A new lignan glucoside, the first 7,9'-monoepoxytetrahydrofuran type lignan with the cis-relationship of H-7 and H-8, named tibeticoside (1), as well as ten known compounds have been isolated from the medicinal plant (roots, stems and leaves) Lancea tibetica. The structure of tibeticoside (1) has been elucidated on the basis of chemical and spectral evidence, especially by 2D-NMR (1H-1H COSY, HMQC, HMBC, NOESY). In addition, sylvatesmin (6) exhibited effective antitumor activity on B16 cells.
antitumor activity, Scrophulariaceae, phenylpropanoid glycosides, Lancea tibetica, lignan glucoside, tibeticoside
NCBI PubMed ID: 10483379Publication DOI: 10.1055/s-1999-14026Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: Jia Z
Institutions: Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China
Methods: 13C NMR, 1H NMR, IR, UV, optical rotation measurement, acetylation, PC, HMBC, antitumor activity assay, HMQC, DEPT, COSY, NOESY, HCl hydrolysis
Found