The novel sesquiterpene lactone glucoside 2α-O-β-D-glucopyranosyl-4α-hydroxy-1α,5α,11α-H-quai-10(14)-en-12,8α-olide (= 2α-hydroxy-11α,13-dihydro-1-epi-inuviscolide-2α-O-β-D-glucopyranoside) was isolated from flowerheads of Arnica mollis. Its structural elucidation was carried out by NMR spectroscopy (1H and 13C NMR, 1H-1H COSY, HMBC, HMQC and 1H-1H NOESY) and mass spectrometry (DCI). Additionally, the lignan (+)-pinoresinol-4′-β-D-glucopyranoside and benzyl-β-glucoside were isolated and identified.
Asteraceae, guaianolide, sesquiterpene lactone glucoside, Arnica mollis, pinoresinol glucoside, benzyl glucoside
Publication DOI: 10.1016/0031-9422(96)00132-XJournal NLM ID: 0151434Publisher: Elsevier
Institutions: Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Geb. 26.23, Universitätsstr. 1, D-40225 Düsseldorf, Germany, Abteilung ZF-D Strukturforschung, Bayer AG Leverkusen, Leverkusen, Germany
Methods: 13C NMR, 1H NMR, TLC, acid hydrolysis, optical rotation measurement, DCI-MS, HMBC, HMQC, COSY, NOESY
Found