From the methanol extract of the roots of (Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3β-O-β-6-deoxyguloside (2), 19-hydroxy-sarmentogenin-3β-O-β-6-deoxyguloside (4), sarmentogenin-3β-O-[α-allosyl-(1→4)-β-6-deoxy alloside] (5), and securigenin-3β-O-[α-allosyl-(1→4)-β-6-deoxyal loside] (6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-o ic acid methylester (11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.
antibacterial activity, cytotoxic activity, diterpene, triterpenes, cardenolides, Celastraceae, Crossopetalum gaumeri, Yucatec Maya, traditional medicine
NCBI PubMed ID: 10939358Publication DOI: 10.1016/s0031-9422(00)00144-8Journal NLM ID: 0151434Publisher: Elsevier
Correspondence: sticher@pharma.ethz.ch
Institutions: Department of Applied Bioscience, Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology (ETH) Zurich, Zürich, Switzerland, Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, London, UK
Methods: 13C NMR, 1H NMR, FAB-MS, TLC, ESI-MS, HPLC, UV, extraction, optical rotation measurement, EI-MS, column chromatography, antibacterial assay, HR-ESI-MS, cytotoxicity assay, MPLC, VLC
Found