Five new triterpenoid saponins, nipponosides A−E (1, 3−6), were isolated from Acanthopanax nipponicus leaves, along with a known saponin, kalopanaxsaponin G (2). Nipponosides A−E were characterized as the 28-O-α-L-rhamnopyranosyl(1→4)-β-D-glucopyranosyl(1→6)-β-D-glucopyranosyl ester of 3-oxohederagenin, oleanolic acid 3-O-β-D-glucopyranoside, gypsogenin 3-O-β-D-glucopyranoside, 3β,23,29-trihydroxyolean-12-en-28-oic acid, and 3β,20α,23-trihydroxy-30-nor-olean-12-en-28-oic acid, respectively. The structures of these new compounds were based on chemical and spectral methods.
triterpenoid saponin, Acanthopanax nipponicus, nipponosides A-E, kalopanaxsaponin G
NCBI PubMed ID: 10096855Publication DOI: 10.1021/np9804334Journal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: Ida Y
Institutions: School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo 142-8555, Japan, okyo Metropolitan Medicinal Plant Garden, Nakajima-cho 21-1, Kodaira, Tokyo 187-0033, Japan
Methods: 13C NMR, 1H NMR, IR, FAB-MS, TLC, GLC, optical rotation measurement, reduction with NaBH4, HMBC, HMQC, COSY, HCl hydrolysis, trimethylsilylation
Found