OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially available dehydroisoandrosterone, L-arabinose, and D-xylose in total 27 steps with the longest linear sequence of 14 steps and in 6% yield.
total synthesis, acylated disaccharide cholestane saponin, antitumor saponin, Ornithogalum saudersiae
NCBI PubMed ID: 11674104Publication DOI: 10.1021/jo981685cJournal NLM ID: 2985193RPublisher: Columbus, OH: American Chemical Society
Correspondence: Hui Y
Institutions: State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
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