Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Acinetobacter baumannii [ICD11:
XN8LS 
]
NCBI PubMed ID: 25917131Publication DOI: 10.1016/j.carres.2015.03.016Journal NLM ID: 0043535Publisher: Elsevier
Correspondence: C. De Castro <decastro
unina.it>
Institutions: School of Molecular Bioscience, The University of Sydney, Sydney, NSW 2006, Australia, Department of Chemical Sciences, Complesso Universitario Monte Sant'Angelo, Napoli, Italy
The structure of the capsular polysaccharide (CPS) from an Acinetobacter baumannii global clone 2 (GC2) clinical isolate RBH4 that carries the KL6 gene cluster was elucidated by means of chemical and spectroscopical methods. The repeating unit of K6 CPS is linear and contains N-acetyl-D-galactosamine (D-GalpNAc), two D-galactose (D-Galp) residues and 5,7-di-N-acetylpseudaminic acid (Pse5Ac7Ac). The synthesis of these sugars could be attributed to genes in the KL6 capsule biosynthesis gene cluster, and the formation of the linkages between the sugars were assigned to glycosyltransferases or the Wzy polymerase encoded in KL6.
capsular polysaccharide, Acinetobacter baumannii, NMR spectroscopy, pseudaminic acid, K locus, KL6 gene cluster
Structure type: polymer chemical repeating unit
Location inside paper: p.34, fig.6, K2
Compound class: CPS
Contained glycoepitopes: IEDB_130648,IEDB_134627,IEDB_136044,IEDB_137472,IEDB_137473,IEDB_141794,IEDB_142488,IEDB_146664,IEDB_147450,IEDB_190606,IEDB_838988,IEDB_838989,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_21,SB_23,SB_24,SB_7,SB_8,SB_88
Methods: 13C NMR, 1H NMR, NMR-2D, methylation, GC-MS, sugar analysis, enzymatic hydrolysis, extraction, acetylation, bioinformatic analysis, dialysis
Biosynthesis and genetic data: genetic data
Related record ID(s): 30619
NCBI Taxonomy refs (TaxIDs): 470Reference(s) to other database(s): GTC:G97931NE
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
report error