Four new withanolide glycosides (1-4) have been isolated from Physalis peruviana. Their structures were established as (20R,22R)-1α-acetoxy-14α,20-dihydroxywitha-5,24-dienolide-3β-(O-β-D-glucopyranoside) (1), (20S,22R)-1α-acetoxy-27-hydroxywitha-5,24-dienolide-3β-(O-β-D-glucopyranoside) (2), (20R,22R)-20,27-dihydroxy-1-oxowitha-5,24-dienolide-3β-(O-β-D-glucopyranoside) (3), and (20R,22R)-14α,20,27-trihydroxy-1-oxowitha-5,24-dienolide-3β-(O-β-D-glucopyranoside) (4) on the basis of spectroscopic data including two dimensional NMR techniques and through chemical transformations.
Solanaceae, withanolide glycoside, Physalis peruviana
Publication DOI: 10.1248/cpb.47.477Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan, Department of Chemistry, Gomal University, Dera Ismail Khan, N.W.F.P., Pakistan
Methods: 13C NMR, 1H NMR, EI-MS, IR, TLC, GC, alkaline hydrolysis, UV, optical rotation measurement, acetylation, PC, HMBC, HMQC, COSY, HR-FAB-MS, HCl hydrolysis, trimethylsilylation
Found