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Structure type: monomer ; 524.3074 [M+H]+
C₂₄H₄₅NO₁₁
Trivial name: bronssonetine L
Compound class: alkaloid
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 11892
  Shibano M, Nakamura S, Motoya N, Kusano G "Studies on the constituents of Broussonetia species. V. Two new pyrrolidine alkaloids, broussonetines K and L, as inhibitors of glycosidase, from Broussonetia kazinoki Sieb." - Chemical and Pharmaceutical Bulletin 47(4) (1999) 472-476
  

  Two new pyrrolidine alkaloids, bronssonetines K and L, were isolated from the branches of Broussonetia kazinoki Sieb. (Moraceae). Broussonetines K and L were formulated as (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(1R)-1-hydroxy-10-oxo-13-(β-D-glucopyranosyloxy) tridecyl] pyrrolidine (1) and (2R,3R,4R,5R)-2-hydroxymethyl-3,4-dihydroxy-5-[(1R)-1-hydroxy-9-oxo-13-(β-D-glucopyranosyloxy) tridecyl] pyrrolidine (2), respectively, by spectroscopic and chemical methods. 1 and 2 inhibited β-glucosidase, β-galactosidase and β-mannosidase.

  Moraceae, pyrrolidine alkaloid, glycosidase inhibitor, Broussonetia kazinoki, broussonetine K, broussonetine L

  Publication DOI: 10.1248/cpb.47.472
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Institutions: Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
  Methods: 13C NMR, 1H NMR, IR, inhibition studies, TLC, HPLC, optical rotation measurement, acetylation, HMBC, acylation, HCl hydrolysis, HR-SI-MS
  
   
  
  Broussonetia kazinoki
  CSDB ID 63389 (all data & tools)