Bulbs of Pancratium maritimum were found to contain a new glucosyloxy phenolic metabolise as well as 14 known Amaryllidaceae alkaloids. The structure of the phenolic metabolite was elucidated by spectroscopic and chemical methods, and it was identified as narciclasine-4-O-β-D-glucopyranoside. When tested in Artemia salina and potato disc assays the new glucoside showed cytotoxic and antitumour activity very similar to narciclasine.
alkaloids, bulbs, Pancratium maritimum, Amaryllidaceae, narciclasine, glucosyloxy alkaloids, narciclasine-4-O-β-D-glucopyranoside
Publication DOI: 10.1016/0031-9422(91)83226-BJournal NLM ID: 0151434Publisher: Elsevier
Institutions: Department of Pharmacognosy, University of Alexandria, Alexandria, Egypt, Istituto per la Chimica di Molecole di Interesse Biologico-CNR, 80072 Arco Felice, Italy, Dipartimento di Scienze Chimico-Agrarie, Università di Napoli “Federico II”, 80055 Portici, Italy, Dipartimento di Chimica Organica e Biologica, Università di Napoli “Federico II”, 80134 Napoli, Italy
Methods: 13C NMR, 1H NMR, EI-MS, IR, FAB-MS, TLC, enzymatic hydrolysis, UV, cytotoxicity assay, antitumor activity assay