From the latex of Lapsana communis L. subps. communis, five guaianolide glycosides were identified: crepiside E, tectoroside and three new ones: 3-O-β-D-glucopyranosyl-8-O-β-acetyl-1αH,5αH,6βH,7αH-guai-4(15),10(14),11(13)-triene-6,12-olide, 3-O-β-D-glucopyranosyl-8-O-β-acetyl-1αH,5αH,6βH,7αH-guai-3(4),10(14),11(13)-triene-15-methyl-6,12-olide, and 3-O-β-glucopyranosyl-8-O-β-(4-hydroxyphenyl)-lactyl-1αH,5αH,6βH,7αH-guai-3(4),10(14),11(13)-triene-15-methyl-6,12-olide. Their structures were established by spectroscopic methods.
Asteraceae, Lactuceae, guaianolides, sesquiterpene lactone glycosides, Lapsana communis subsp. communis
NCBI PubMed ID: 10444857Publication DOI: 10.1016/S0031-9422(98)00718-3Journal NLM ID: 0151434Publisher: Elsevier
Institutions: Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, University of Tours, 31 Avenue Monge, 37 200 Tours, France, Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Tours, 31 Avenue Monge, 37 200 Tours, France, Department of Biophysic, Army Research Center of Health, 38 702 La Tronche, France
Methods: 13C NMR, 1H NMR, NOE, EI-MS, FAB-MS, TLC, HPLC, CI-MS, cytotoxicity assay, DEPT, NOESY, HOHAHA, DFQ-COSY