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Taxonomic group: bacteria / Proteobacteria (Phylum: Proteobacteria)
Host organism: Homo sapiens
Associated disease: nosocomial infections [ICD11: XB25

]; infection due to Acinetobacter baumannii [ICD11: XN8LS

]

NCBI PubMed ID: 26531136
Publication DOI: 10.1016/j.carres.2015.10.001
Journal NLM ID: 0043535
Publisher: Elsevier
Correspondence: denis.giguere

chm.ulaval.ca
Institutions: Département de Chimie, Université Laval, Québec City, Québec, Canada G1V 0A6

The emergence of multidrug-resistance Acinetobacter baumannii requires novel approaches for prevention, treatment and diagnosis. The structures of surface polysaccharides from A. baumannii are valuable tools to understand pathogenesis, virulence and immunogenicity. The synthesis of bacterial mono- or polysaccharides may result in novel probes to become important therapeutic options in the fight against A. baumannii. This report exemplifies the relevance of glycochemistry for the development of new antibiotics.

lipopolysaccharides, capsular polysaccharides, Acinetobacter, Acinetobacter baumannii, polysaccharide synthesis, surface polysaccharides

Structure type: polymer chemical repeating unit
Location inside paper: p.32, table 1, strain NIPH 615 (KL48)
Compound class: CPS
Contained glycoepitopes: IEDB_135813,IEDB_136906,IEDB_137340,IEDB_137472,IEDB_141794,IEDB_141807,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_151531,IEDB_190606,IEDB_983931,SB_192,SB_7

Comments, role: minireview; CPS (the capsule biosynthesis gene locus KL48 has been characterized).

NCBI Taxonomy refs (TaxIDs): 1217641
Reference(s) to other database(s): GTC:G35428RP
Show glycosyltransferases

There is only one chemically distinct structure:

[*]O[C@H]1[C@H](O)[C@@H](CO)O[C@H](OC[C@H]2O[C@H](O[C@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](NC(C)=O)[C@H]([*])O[C@H](CO)[C@H]4O)[C@H](O)[C@H]3O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H](NC(C)=O)[C@@H](O)[C@@H]2O)[C@@H]1O

SVG MW SMILES 3D mol Ionize