An extract from the entire Ixriss denticulata f. pinnatipartita plant afforded the guaianolide sesquiterpene lactone glucoside, 8β,15-dihydroxy-1(10),3,11(13)-guaiatrien-12,6-olide-15-O-glucopyranoside, along with the known flavonoids luteolin-7-O-glucoside and luteolin-7-O-glucuronide-6'-methyl ester; their structures were determined by spectroscopic methods. Ixerin Y inhibited the growth of human breast cancer MCF7 and MDA468 cell lines.
cytotoxicity, compositae, Ixeris denticulata f. pinnatipartita Kitag, ixerin Y, luteolin-7-O-glucoside, luteolin-7-O-glucuronide-6′-methyl ester
NCBI PubMed ID: 9891935Publication DOI: 10.1016/S0031-9422(98)00452-XJournal NLM ID: 0151434Publisher: Elsevier
Institutions: Pharmanex Shanghai R&D Center, 12th Floor, Zhidao Tower, Shanghai Medical University, 200032 Shanghai, China, Department of Pharmacognosy, China Pharmaceutical University, No. 1 Shennong Rd, Nangjing 210038, China
Methods: 13C NMR, 1H NMR, EI-MS, IR, TLC, UV, hydrolysis, cytotoxicity assay, HMBC, HMQC, DEPT, COSY, NOESY
Found