Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isoplumericin and plumericin. In addition, the new lignan 7(R)-methoxy-8-epi-matairesional and three known compounds, plumieride, matairesinol, and pinoresinol, were isolated from H. fallax.
cytotoxicity, Iridoids, bioassay, Allamanda cathartica, Himatanthus fallax, Suriname rainforest
NCBI PubMed ID: 9428163Publication DOI: 10.1021/np970253eJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Institutions: Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, USA, Bedrijf Geneesmiddelen Voorziening Suriname, Paramaribo, Suriname, Missouri Botanical Garden, St. Louis, USA
Methods: 13C NMR, 1H NMR, methylation, TLC, biological assays, extraction, optical rotation measurement, acetylation, CD, chromatography, CC, melting point determination, cytotoxicity assay, evaporation, flash chromatography, LR-MS, HR-EI-MS, VLC
Found