Five new megastigmane glucosides and one of their aglycones were isolated, along with (6S,9R)-roseoside, from the polar fraction of the leaves of Asclepias fruticosa, and the structures were determined by spectroscopic methods. Most of them have an epoxy-linkage between C-5 and C-11. The configurations at C-3 and C-9 for each compound were confirmed to be S and R, respectively, by application of the modified Mosher's method.
5, Asclepiadaceae, 11-epoxymegastigmane, ascleposide, Asclepias fruticosa
NCBI PubMed ID: 11145142Publication DOI: 10.1248/cpb.48.1908Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Correspondence: abefumi@fukuoka-u.ac.jp
Institutions: Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, enzymatic hydrolysis, extraction, optical rotation measurement, CC, evaporation, HR-FAB-MS
Found