Thirteen compounds have been isolated from the methanol extract of Saxifraga cuneifolia L. (Saxifragaceae) whole plant. These were identified as five new compounds, (E)-5-O-β-D-glucopyranosyl-stilbene-3,3', 4,5'-tetraol, (E)-4-O-β-D-glucopyranosyl-5-methoxy-stilbene-3,3',5'-triol, 4-[4'-O-(6''-O-galloyl-β-D-glucopyranosyl)-3'-hydroxyphenyl]butan-2-one, 3-O-(6''-O-galloyl-β-D-glucopyranosyl)-epigallocatechin and 3-O-β-D-glucopyranosyl-epigallocatechin, together with the known compounds 4-[4'-O-β-D-glucopyranosyl-3'-hydroxyphenyl]-butan-2-one, (R)-rhododendrin, 1-O-galloyl-β-D-glucose, catechin, 3-O-galloyl-epigallocatechin, gallocatechin, clitorin and rutin, by chemical and spectroscopic methods. Their free radical scavenging properties are also described.
flavonoid glycosides, free radical scavengers, Saxifragaceae, catechin derivatives, phenylbutan-2-one glycosides, (R)-rhododendrin, Saxifraga cuneifolia, stilbene glycosides
NCBI PubMed ID: 21214466Publication DOI: 10.1076/1388-0209(200007)3831-SFT222Journal NLM ID: 9812552Publisher: Lisse, the Netherlands: Swets & Zeitlinger
Correspondence: kurt.hostettmann@ipp.unil.ch
Institutions: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Lausanne, Switzerland
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, ESI-MS/MS, HPLC, alkaline hydrolysis, UV, enzymatic digestion, extraction, optical rotation measurement, CC, melting point determination, radical reduction assay
Found