Six compounds have been isolated from the methanol extract of the aerial parts of Gnidia involucrata (Thymelaeaceae). They were identified as 2,3,4',5,6-pentahydroxybenzophenone-4-C-glucoside and 2,4',6-trihydroxy-4-methoxybenzophenone-2-O-glucoside, together with mangiferin, kaempferol-3-O-glucoside, yuankanin and manniflavanone by chemical and spectroscopic means. The structures of three additional C-glycosyl flavones--vitexin, isovitexin and isoorientin--were determined on-line by LC/UV/APCI-MSn analysis of the crude extract.
Thymelaeaceae, Gnidia involucrata, benzophenone glycosides, biЇavanone, yuankanin, mangiferin, manniflavanone, flavonoid C-glycosides
NCBI PubMed ID: 11014283Publication DOI: 10.1016/s0031-9422(00)00046-7Journal NLM ID: 0151434Publisher: Elsevier
Correspondence: kurt.hostettmann@ipp.unil.ch
Institutions: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland, Department of Chemistry, University of Swaziland, Kwaluseni, Swaziland
Methods: 13C NMR, 1H NMR, EI-MS, methylation, gel filtration, NMR-2D, acid hydrolysis, UV, extraction, optical rotation measurement, DCI-MS, CC, melting point determination, evaporation, MPLC, LPLC, APCI-MS