Eight new triterpene glycosides named cimiracemosides A−H, respectively, and eight known triterpene glycosides were isolated from the rhizome extracts of black cohosh (Cimicifuga racemosa). The new compounds were determined by spectral data to be 21-hydroxycimigenol-3-O-α-l-arabinopyranoside (1), 21-hydroxycimigenol-3-O-β-d-xylopyranoside (2), cimigenol-3-O-α-l-arabinopyranoside (3), 12β-acetoxycimigenol-3-O-α-l-arabinopyranoside (4), 24-acetylisodahurinol-3-O-β-d-xylopyranoside (5), 20(S),22(R),23(S),24(R)-16β:23;22:25-diepoxy-12β-acetoxy-3β,23,24-trihydroxy-9,19-cycloanost-7-ene-3-O-β-d-xylopyranoside (6), 20(S),22(R),23(S),24(R)-16β:23;22:25-diepoxy-12β-acetoxy-3β,23,24-trihydroxy-9,19-cycloanost-7-en-3-O-α-l-arabinopyranoside (7), and 20(S),22(R),23(S),24(R)-16β:23;22:25-diepoxy-12β-acetoxy-3β,23,24-trihydroxy-9,19-cycloanostane-3-O-β-d-xylopyranoside (8).
triterpene glycosides, Cimicifuga racemosa, black cohosh, cimiracemosides A-H
NCBI PubMed ID: 10924163Publication DOI: 10.1021/np000047yJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: shaoy@ahp.com
Institutions: Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA, Solgar Research Center for Excellence, Solgar Vitamin and Herb Company, Richmond, USA
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