Three new cycloartane bisdesmosides, two of which are based on a new genin, were isolated from the above-ground parts of Thalictrum minus. Thalicosides A1−A3 (1−3) were characterized as 3-O-β-D-galactopyranosyl-29-O-β-D-glucopyranosyl-3β,16β,29-trihydroxy-22(S),25-epoxycycloartane (1); 3-O-α-L-arabinopyranosyl-29-O-β-D-glucopyranosyl-3β,16β,29,22(S)-tetrahydroxycycloart-24-ene (2); and 3-O-α-L-arabinopyranosyl-29-O-β-D-glucopyranosyl-3β,16β,29-trihydroxy-22(S),25-epoxycycloartane (3), respectively. The structural assignments of these new compounds were based on interpretation of spectroscopic data. Thalicoside A2 showed in vitro inhibition of the fungus Candida albicans and also activity against Staphylococcus aureus.
thalicosides, cycloartane bidesmosides, Thalictrum minus, antifungal and antibacterial activity
NCBI PubMed ID: 10924164Publication DOI: 10.1021/np000017vJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: noel_owen@byu.edu
Institutions: Department of Chemistry, University of Utah, Salt Lake City, USA, Department of Chemistry and Biochemistry, Brigham Young University, Provo, USA, Irkutsk Institute of Chemistry, Siberian Branch of the RAS, Irkutsk, Russia
Methods: 13C NMR, 1H NMR, NMR-2D, IR, TLC, UV, extraction, optical rotation measurement, CC, melting point determination, antibacterial assay, evaporation, antifungal activity test, HR-FAB-MS, HR-EI-MS
Found