Four new triterpenoid saponins were isolated and identified from the aerial parts of Fagonia cretica. They were characterized as 3-O-[β-D-glucopyranosyl (1→2)-α-L-arabinopyranosyl] hederagenin 28-O-β-D-glucopyranosyl ester, 3-O-[β-D-glucopyranosyl (1→2)-α-L-arabinopyranosyl] oleanolic acid 28-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] ester, 3-O-[β-D-glucopyranosyl (1→2)-α-L-arabinopyranosyl] 27-hydroxy oleanolic acid 28-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] ester and 3β-O-[β-D-glucopyranosyl (1→2)-α-L-arabinopyranosyl] olean-12-en-27-al-28-oic acid 28-O-[β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl] ester. The structures of the saponins were assigned by spectral analyses (FABMS, 1H, 13C NMR, 1H–1H COSY, TOCSY, HMQC and HMBC spectra) and NOE experiments. To the best of our knowledge the genin 3β hydroxy olean-12-en-27-al-28-oic acid is new.
triterpenoid saponins, Zygophyllaceae, Fagonia cretica
NCBI PubMed ID: 11014278Publication DOI: 10.1016/s0031-9422(00)00168-0Journal NLM ID: 0151434Publisher: Elsevier
Correspondence: Melek FR
Institutions: School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, Pharmacognosy Department, Helwan University, Cairo, Egypt, Chemistry of Natural Products Department, National Research Center, Cairo, Egypt
Methods: 13C NMR, 1H NMR, FAB-MS, GC, HPLC, extraction, optical rotation measurement
Found