Chromatographic separation of ethanolic root extracts of Taraxacum laevigatum and Taraxacum disseminatum afforded a total of eight germacrane- and eudesmane-type sesquiterpenoids, including new compounds, 1β,3β,6α-trihydroxy-4α(15)-dihydrocostic acid methyl ester and its 1-O-β-glucopyranoside. Their structures were established by spectroscopic analyses. In addition, the structure of 4α(15),11β(13)-tetrahydroridentin B-1-O-β-glucopyranoside was elucidated by extensive NMR studies.
Taraxacum laevigatum; Taraxacum disseminatum; Asteraceae; Lactuceae; sesquiterpenoids; germacranolides; eudesmanolides; costic acid derivatives; glycosides
NCBI PubMed ID: 11014267Publication DOI: 10.1016/s0031-9422(00)00088-1Journal NLM ID: 0151434Publisher: Elsevier
Correspondence: kisielw@rabbit.if-pan.krakow.pl
Institutions: Department of Phytochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, ESI-MS, acid hydrolysis, HPLC, extraction, CC, HR-ESI-MS, evaporation, centrifugation