A novel polyoxygenated 5β-cholestane diglycoside, named galtonioside A, was isolated from the bulbs of Galtonia candicans by way of a cytotoxicity-guided fractionation procedure against HL-60 leukemia cells. Galtonioside A showed differential cytotoxicity in the Jpn. Fdn. for Cancer Res. 38 cell line assay.
glycoside, structure-activity, steroid, cytotoxic, cytotoxic compound
Publication DOI: 10.1016/S0040-4039(99)02058-4Journal NLM ID: 2984819RPublisher: Elsevier
Correspondence: mimakiy@ps.toyaku.ac.jp
Institutions: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan