A novel cholestane diglycoside, named candicanoside A (1), was isolated from the bulbs of Galtonia candicans by monitoring the cytotoxic activity on HL-60 leukemia cells. Candicanoside A (1) is very unique in structure, having two epoxy functionalities in its rearranged cholestane skeleton, and showed differential cytotoxicity in the Japanese Foundation for Cancer Research 38 cell-line assay.
cytotoxicity, HL-60 leukemia cells, candicanoside A, Galtonia candicans
Publication DOI: 10.1002/1522-2675(20001004)83:10<2698::AID-HLCA2698>3.0.CO;2-4Journal NLM ID: 2985094RPublisher: Verlag Helvetica Chimica Acta
Correspondence: mimakiy@ps.toyaku.ac.jp
Institutions: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
Methods: 13C NMR, 1H NMR, EI-MS, NMR-2D, TLC, HPLC, extraction, evaporation, centrifugation, HR-EI-MS
Found