A novel cucurbitacin glycoside has been isolated from aerial parts of Kageneckia oblonga R. et P. and shown to be 3β-(β-D-glucosyloxy)-16α,23α-epoxycucurbita-5,24-dien-11-one. The structure was established by usual spectroscopic and two-dimensional (2D) NMR techniques. This compound has found to be nontoxic when tested in-vivo cell culture assays. In previous investigations we reported 23,24-dihydrocucurbitacin F and prunasine. This was the first report on cucurbitacins from the genus Kageneckia (Rosaceae).
rosaceae, cucurbitacin, Kageneckia oblonga
NCBI PubMed ID: 10817201Publication DOI: 10.1515/znc-2000-3-403Journal NLM ID: 8912155Publisher: Verlag der Zeitschrift für Naturforschung
Correspondence: omunoz@abello.die.uehile.el
Institutions: Departamento de Química, Faeultad de Cieneias, Universidad de Chile, Santiago, Chile, Departamento de Química Farmacolögica y Toxicológica, Facultad de Ciencias Químicas y Farmaceuticas, Universidad de Chile, Santiago, Chile, Departamento de Química Farmaceutica, Faeultad de Farmacia, Universidad de Salamanca, Salamanca, España
Methods: 13C NMR, 1H NMR, EI-MS, NMR-2D, TLC, HPLC, extraction, evaporation, centrifugation, HR-EI-MS
Found