Three galloyl monosaccharides contained in medicinal plants were examined for apoptosis-inducing activity in human histiocytic lymphoma U937 cells. Tetragalloyl glucose (TgG) induced apoptosis as found by chromatin condensation, DNA ladder formation, and inhibition by a caspase inhibitor. Digalloyl hamamelose had moderate activity, while monogalloyl glucose was only marginally active. These findings suggest that the number and disposition of their phenolic groups are important for apoptosis induction. TgG induced apoptosis in human colon and stomach cancer cell lines as well, indicating it is potentially useful as an anti-cancer agent.
apoptosis, tetragalloyl glucose, digalloyl hamamelose, monogalloyl glucose, epigallocatechin gallate, caspase inhibitor
NCBI PubMed ID: 10763584Publication DOI: 10.1055/s-2000-11121Journal NLM ID: 0066751Publisher: George Thieme
Correspondence: isemura@fns1.u-shizuoka-ken.ac.jp
Institutions: School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Methods: biological assays
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