Show legend Show as text

Structure type: monomer
Trivial name: broussonetine O
Compound class: glycoside
Contained glycoepitopes: IEDB_142488,IEDB_146664,IEDB_983931,SB_192

• Article ID: 12687
  Shibano M, Tsukamoto D, Fujimoto R, Masui Y, Sugimoto H, Kusano G "Studies on the constituents of Broussonetia species. VII. Four new pyrrolidine alkaloids, broussonetines M, O, P, and Q, as inhibitors of glycosidase, from Broussonetia kazinoki Sieb." - Chemical and Pharmaceutical Bulletin 48(9) (2000) 1281-1285
  

  Four new pyrrolidine alkaloids, broussonetines M, O, P, and Q, were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines M, O, P, and Q were formulated as (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-[(10S)-10, 13-dihydroxy-tridecyl]pyrrolidine (1), (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-[(E)9-oxo-13-hydroxy-3-tridecenyl]pyrrolidine (2), (2R, 3R, 4R, 5R)-2-hydroxymethyl-3, 4-dihydroxy-5-[(E)10-oxo-13-hydroxy-3-tridecenyl]pyrrolidine (3), and (2R, 3R, 4R, 5R)-2-hydroxymethyl-3-hydroxy-4-(β-D-glucopyranosyloxy)-5-[10-oxo-13-(β-D-glucopyranosyloxy)tridecyl]pyrrolidine (4) respectively, by spectroscopic and chemical methods. 1-4 inhibited β-glucosidase, β-galactosidase and β-mannosidase.

  Moraceae, pyrrolidine alkaloid, glycosidase inhibitor, Broussonetia kazinoki

  NCBI PubMed ID: 10993225
  Publication DOI: 10.1248/cpb.48.1281
  Journal NLM ID: 0377775
  Publisher: Pharmaceutical Society Of Japan
  Correspondence: kusano@oups.ac.jp
  Institutions: Osaka University of Pharmaceutical Sciences, Takatsuki, Japan
  
   
  
  Broussonetia kazinoki
  CSDB ID 67882 (all data & tools)