Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.
structure, Aglaia laxiflora, rocaglaol rhamnoside
NCBI PubMed ID: 10785416Publication DOI: 10.1021/np990454dJournal NLM ID: 7906882Publisher: American Society of Pharmacognosy
Correspondence: chmgsh@leonis.nus.edu.sg
Institutions: Department of Chemistry, National University of Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Forest Research Center, Sepilok, Malaysia, Forest Research Institute of Malaysia, Kepong, Malaysia
Methods: 13C NMR, 1H NMR, NMR-2D, FAB-MS, TLC, ESI-MS, HPLC, extraction, CC
Found