Phytochemical studies on the stem bark of Thevetia peruviana resulted in the isolation of six new ursane-type triterpenes, named peruvianursenyl acetate A, peruvianursenyl acetate B, isolupenyl acetate, peruvianursenyl acetate C, lupedienyl acetate and peruvianursenyl glucoside along with two known triterpenoids, namely alpha-amyrin acetate and lupeol acetate. The structures of the new phytoconstituents have been established as 23-normethyl-urs-12-en-4α-ethylenic-18α-H-3β-yl acetate, urs-5.21-dien-18α-H-3β-yl acetate, lup-20(29)-en-3α-yl acetate, urs-12 en-18α-H-3β-yl acetate, lup-5,20(29)-dien-3β-yl acetate, and urs-12-en-18α-H-3-O-β-D-glucopyranoside, respectively.
NCBI PubMed ID: 11828622Journal NLM ID: 9800766Publisher: Eschborn: Govi-Verlag Pharmazautischer Verlag
Correspondence: m.ali@mail.usa.com.hascritto
Institutions: Faculty of Pharmacy, Hamdard University, New Delhi, India
Methods: 13C NMR, 1H NMR, NMR-2D, TLC, enzymatic hydrolysis, acid hydrolysis, HPLC, optical rotation measurement, HR-FAB-MS
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