Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
Associated disease: infection due to Haemophilus influenzae [ICD11:
XN1P6 
]
The structure was elucidated in this paperNCBI PubMed ID: 11015221Journal NLM ID: 0370623Publisher: American Chemical Society
Correspondence: leary
socrates.berkeley.edu
Institutions: Department of Chemistry, University of California, Berkeley, California 94720, USA, Departament of Phrmaceutical Chemistry, University of California, San Francisco, California 94143
Lipooligosaccharide (LOS) glycoforms from Haemophilus influenzae 2019 were profiled using the high-resolution and accurate mass capabilities of Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry. Sequence and linkage for two previously unknown LOS glycoforms were subsequently obtained through MSn analyses on FT-ICR and quadrupole ion trap (qIT) instruments. MSn analysis of negative ion precursors confirmed structural details within the lipid moiety, while CID spectra of sodiated precursor ions provided monosaccharide sequence and linkage for the oligosaccharide portion of the molecule. Results obtained in this study indicate that extensive heterogeneity exists within the oligosaccharide moieties in LOS from H. influenzae 2019. More importantly, the data suggest that additional hexose moieties, which are added onto the LOS, are not simple extensions of one particular core structure but rather that structural isomers with different connectivities are present within the heterogeneous mixture.
Haemophilus, Haemophilus influenzae, Lipooligosaccharide, characterization, lipooligosaccharides
Structure type: oligomer
Location inside paper: Figure 2, p.12409
Aglycon: lipid A
Compound class: LOS
Contained glycoepitopes: IEDB_130650,IEDB_136044,IEDB_137472,IEDB_137777,IEDB_137779,IEDB_138949,IEDB_140087,IEDB_140088,IEDB_140090,IEDB_141794,IEDB_142487,IEDB_142488,IEDB_146664,IEDB_190606,IEDB_2189047,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_6,SB_7,SB_88
Methods: dephosphorylation, ESI-FTICR-MS, de-O-acetylation, qIT-MS
Comments, role: Major LOS (lipooligosaccharide) from Haemophilus influenzae 2019 (the LOS contains ethanoaminephosphate groups linked at unknown position of heptose residues in the side chain). Other LOSs described in the paper are impracticable for recording.
Related record ID(s): 14
NCBI Taxonomy refs (TaxIDs): 1232659Reference(s) to other database(s): GTC:G15388DM, GlycomeDB:
25037
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There is only one chemically distinct structure:
Found 
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