Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
NCBI PubMed ID: 34022313Publication DOI: 10.1016/j.ijbiomac.2021.05.112Journal NLM ID: 7909578Publisher: Butterworth-Heinemann
Correspondence: Leal LKAM <kalyne
ufc.br>; Ribeiro MENP <elenir.ribeiro
ufc.br>; Ricardo NMPS <naricard
ufc.br>
Institutions: Laboratório de Polímeros e Inovação de Materiais, Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Brasil, Centro de Estudos Farmacêuticos e Cosméticos, Departamento de Farmácia, Universidade Federal do Ceará, Fortaleza, Brasil
Edible mushrooms have been increasingly introduced into the human diet, which has driven research into their functional properties. Thus, Agaricus brasiliensis Murill or Agaricus blazei Murill (ABM) is a species native to the Brazilian biome, whose fruiting body has been used not only for dietary purposes, but also in the development of functional foods or as source of molecules of pharmacological interest. The bioactivity of ABM has been related to the presence of polysaccharides, although the contribution of other metabolites cannot be discharged. This work describes the polysaccharides isolation methodology and preparation of the extracts of ABM and their biological activities. Furthermore, it presents a general outline of its characterizations regarding composition, chemical structure and properties in solution. The ABM and its chemical constituents exhibit several biological activities that support their potential use for prevention or treatment of diseases with inflammatory background, such as cancer, diabetes and atherosclerosis. The mechanism of action of the extracts and polysaccharides from ABM is mainly related to a modulation of immune system response or reduction of inflammatory response. This review shows that the ABM has great potential in the pharmaceutical, biotechnological and food sectors that deserves additional research using standardized products.
Agaricus brasiliensis Murill or Agaricus blazei Murill mushroom, immunomodulatory activity and anti-inflammatory activity, polysaccharides and extracts
Structure type: homopolymer ; 7300000
Location inside paper: p. 1703, Table 3
Compound class: glucan, polysaccharide
Contained glycoepitopes: IEDB_140629,IEDB_142488,IEDB_144998,IEDB_146664,IEDB_420417,IEDB_420418,IEDB_420421,IEDB_857742,IEDB_983931,SB_192
Comments, role: review
Related record ID(s): 40909
NCBI Taxonomy refs (TaxIDs): 307931
Show glycosyltransferases
There is only one chemically distinct structure:
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