Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: mycelium
NCBI PubMed ID: 34361662Publication DOI: 10.3390/molecules26154510Journal NLM ID: 100964009Publisher: Basel, Switzerland: MDPI
Correspondence: C.F. Kuo <drkuo
g2.usc.edu.tw>
Institutions: Department of Food Science, Nutrition, and Nutraceutical Biotechnology, Shih Chien University, Taipei 10462, Taiwan, Biotech Research Institute, Grape King Bio Ltd., Taoyuan 32542, Taiwan
Erinacine A, derived from the mycelia of Hericium erinaceus, has attracted much attention due to its neuroprotective properties. However, very few studies have been conducted on the bioavailability, tissue distribution, and protein binding of erinacine A. This study aimed to investigate the bioavailability, tissue distribution, and protein binding of erinacine A in Sprague-Dawley rats. After oral administration (po) and intravenous administration (iv) of 2.381 g/kg BW of the H. erinaceus mycelia extract (equivalent to 50 mg/kg BW of erinacine A) and 5 mg/kg BW of erinacine A, respectively, the absolute bioavailability of erinacine A was estimated as 24.39%. Erinacine A was detected in brain at 1 h after oral dosing and reached the peak at 8 h. Protein binding assay showed unbound erinacine A fractions in brain to blood ratio is close to unity, supporting passive diffusion as the dominating transport. Feces was the major route for the elimination of erinacine A. This study is the first to show that erinacine A can penetrate the blood-brain barrier of rats by the means of passive diffusion and thus support the development of H. erinaceus mycelia for the improvement of neurohealth.
Hericium erinaceus, mycelium, nutrition
Structure type: monomer
Location inside paper: Fig. 1, erinacine A
Trivial name: erinacine A
Compound class: glycoside, diterpene glycoside
Contained glycoepitopes: IEDB_114701,IEDB_167188,IEDB_174332
Methods: HPLC, LC-MS/MS, bioassay, pharmacokinetic study, protein binding assay
NCBI Taxonomy refs (TaxIDs): 91752
Show glycosyltransferases
There is only one chemically distinct structure:
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