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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Organ / tissue: fruiting bodies

NCBI PubMed ID: 36671814
Publication DOI: 10.3390/biology12010122
Journal NLM ID: 101587988
Publisher: Basel, Switzerland: MDPI
Correspondence: R. HT <rjun

zjut.edu.cn>; P. Sun <sun_pl

zjut.edu.cn>
Institutions: College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China, Zhejiang Fangge Pharmaceutical Co., Ltd., Qingyuan 323800, China, Bioactives and Functional Foods Research Center, China National Light Industry, Hangzhou 310014, China, Key Laboratory of Food Macromolecular Resources Processing Technology Research, China National Light Industry, Hangzhou 310014, China

Mushroom polysaccharides are a kind of biological macromolecule extracted from the fruiting body, mycelium or fermentation liquid of edible fungi. In recent years, the research on mushroom polysaccharides for alleviating metabolic diseases, inflammatory bowel diseases, cancers and other symptoms by changing the intestinal microenvironment has been increasing. Mushroom polysaccharides could promote human health by regulating gut microbiota, increasing the production of short-chain fatty acids, improving intestinal mucosal barrier, regulating lipid metabolism and activating specific signaling pathways. Notably, these biological activities are closely related to the molecular weight, monosaccharide composition and type of the glycosidic bond of mushroom polysaccharide. This review aims to summarize the latest studies: (1) Regulatory effects of mushroom polysaccharides on gut microbiota; (2) The effect of mushroom polysaccharide structure on gut microbiota; (3) Metabolism of mushroom polysaccharides by gut microbiota; and (4) Effects of mushroom polysaccharides on gut microbe-mediated diseases. It provides a theoretical basis for further exploring the mechanism of mushroom polysaccharides for regulating gut microbiota and gives a reference for developing and utilizing mushroom polysaccharides as promising prebiotics in the future.

inflammatory bowel disease, gut microbiota, diabetes mellitus, mushroom polysaccharides, obesity, cancers, non-alcoholic fatty liver disease

Structure type: fragment of a bigger structure
Location inside paper: Fig. 1D, EPA-1
Compound class: polysaccharide EPA-1

Comments, role: review; part of proposed EPA-1 polysaccharide complex stucture, which consists of successively linked ID 41526 and ID 41527 from ref. [34] Xu DD et al., Int. J. Biol. Macromol. 2016, 92, 30-36, DOI: 10.1016/j.ijbiomac.2016.07.016.

NCBI Taxonomy refs (TaxIDs): 5323
Show glycosyltransferases

There is only one chemically distinct structure:

[*]OC[C@H]1OC(OC[C@H]2OC(OC[C@H]3OC(OC[C@H]4OC(OC[C@H]5OC(O[C@H]6[C@@H](O)[C@@H](CO)OC(OC[C@H]7OC([*])[C@H](O)[C@@H](O)[C@H]7O)[C@@H]6OC6O[C@H](CO)[C@@H](O)[C@H](OC7O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]7O)[C@H]6O)[C@@H](O)[C@@H](OC6O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]6O)[C@@H]5O)[C@H](O)[C@@H](O)[C@H]4O)[C@H](O)[C@@H](O)[C@H]3O)[C@H](OC3O[C@H](CO)[C@@H](O)[C@H](OC4O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@H]3O)[C@@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

SVG MW SMILES 3D mol Ionize

zjut.edu.cn>; P. Sun <sun_pl

inflammatory bowel disease, gut microbiota, diabetes mellitus, mushroom polysaccharides, obesity, cancers, non-alcoholic fatty liver disease

There is only one chemically distinct structure:

[*]O[C@@H]1[C@@H](O)C(OC[C@H]2OC([*])[C@@H](O)[C@@H](O)[C@@H]2O)O[C@H](CO)[C@@H]1O

SVG MW SMILES 3D mol Ionize