Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
Publication DOI: 10.1016/j.jiec.2024.01.024Journal NLM ID: 101737974Publisher: Amsterdam: Elsevier
Correspondence: Gopal J <jejudy777
gmail.com>; Oh J-W <ohjw
konkuk.ac.kr>
Institutions: Department of Bio-resources and Food Science, Konkuk University, Seoul, South Korea, Department of Stem Cell and Regenerative Biotechnology, KIT, Konkuk University, Seoul, South Korea, Department of Research and Innovation, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, India
Mushrooms have been known as the elixirs of health, they are well known from ages immemorial for their nutritional and medicinal properties immunoceutical and immunomodulatory properties. Lentinula edodes (“shiitake”) is a well-accomplished mushroom for its biological and medicinal attributes of huge significance. Lentinan is a bioactive polysaccharide that is extracted from shiitake mushrooms. In the present study, standard commercially available lentinan polysaccharide was used to demonstrate its anticancer activity. The results confirmed the anti-cancer cell proliferative effect of lentinan on colon and gastric cancer cell lines through the inhibition of G2/M phase in the cell cycle. Lentinan also could attenuate wound healing and colony formation abilities and migration in AGS and HT-29 cells, demonstrating its tumorigenesis potential. Lentinan could increase phospho-p38 and decrease phopho-ERK1/2, Mu-2-related death-inducing gene (MuD) protein. Besides, lentinan also induced reactive oxygen species (ROS) production which was directly involved in cell death. In this study, various aspects of the anticarcinogenic activity of lentinan including the MuD in uence have been demonstrated. This is the first report evidencing cross-talk by lentinan and MuD protein confiming the anti-apoptotic function of lentinan
polysaccharide, lentinan, antitumorigenic
Structure type: structural motif or average structure
Location inside paper: Fig. 1
Trivial name: lentinan
Compound class: O-polysaccharide, glucan, polysaccharide, β-glucan
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: immunoblotting, flow cytometry, ROS measurement, cell viability, wound healing assay, cell cycle assay, DAPI staining assay
Biological activity: lentinan retards cell proliferation in AGS and HT-29 cells through inhibition of G2/M phase in the cell cycle. Lentinan also could attenuate wound healing and colony formation capacity, migration in AGS and HT-29 cells, whereby demonstrating its tumorigenesis potential. Lentinan could increase phospho-p38 and decrease phopho-ERK1/2 and MuD. Besides, lentinan also induced reactive oxygen species (ROS) production which was directly involved in cell death
Related record ID(s): 41647, 42492, 44461, 44479, 44486, 45278, 45824, 46521, 48490, 50612, 50618, 50634, 50650, 50651, 50657, 50661, 50666, 50675, 50678
NCBI Taxonomy refs (TaxIDs): 5353Reference(s) to other database(s): GTC:G14698DR
Show glycosyltransferases
There is only one chemically distinct structure:
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