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Liu JJ, Hou YK, Wang X, Zhou XT, Yin JY, Nie SP
Recent advances in the biosynthesis of fungal glucan structural diversity
Carbohydrate Polymers 329 (2024)
ID 121782
|
/Variants 0/-+
|
-4)-a-D-Glcp-(1-4)-a-D-Glcp-(1-4)-a-D-Glcp-(1-4)-a-D-Glcp-(1-
/Variants 0/ is:
a-D-Glcp-(1-6)-
OR (exclusively)
a-L-Fucp-(1-6)-
OR (exclusively)
a-D-Galp-(1-6)- |
Show graphically |
Agrocybe cylindracea
(later renamed to: Cyclocybe cylindracea)
(NCBI TaxID 1593264,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
NCBI PubMed ID: 38286552Publication DOI: 10.1016/j.carbpol.2024.121782Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Yin JY <yinjy

ncu.edu.cn>; Nie SP <spnie

ncu.edu.cn>
Institutions: State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang, China, Food Laboratory of Zhongyuan, Henan, China
Glucans are the most abundant class of macromolecule polymers in fungi, which are commonly found in Ascomycota and Basidiomycota. Fungal glucans are not only essential for cell integrity and function but also crucial for the immense industrial interest in high value applications. They present a variety of structural characteristics at the nanoscale due to the high regulation of genes and the involvement of stochastic processes in synthesis. However, although recent findings have demonstrated the genes of glucans synthesis are relatively conserved across diverse fungi, the formation and organization of diverse glucan structures is still unclear in fungi. Here, we summarize the structural features of fungal glucans and the recent developments in the mechanisms of glucans biosynthesis. Furthermore, we propose the engineering strategies of targeted glucan synthesis and point out the remaining challenges in the synthetic process. Understanding the synthesis process of diverse glucans is necessary for tailoring high value glucan towards specific applications. This engineering strategy contributes to enable the sustainable and efficient production of glucan diversity
biosynthesis, gene, diversity, glucan, fungi, target glucan
Structure type: structural motif or average structure
Location inside paper: Fig. 1, fucogalactoglucan, structure 1
Compound class: polysaccharide, fucogalactoglucan
Contained glycoepitopes: IEDB_136045,IEDB_136906,IEDB_137472,IEDB_140529,IEDB_140629,IEDB_141794,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_152214,IEDB_174333,IEDB_190606,IEDB_420417,IEDB_420418,IEDB_420419,IEDB_420421,IEDB_857742,IEDB_983931,SB_192,SB_7,SB_86
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 1593264
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There is only one chemically distinct structure:
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Liu JJ, Hou YK, Wang X, Zhou XT, Yin JY, Nie SP
Recent advances in the biosynthesis of fungal glucan structural diversity
Carbohydrate Polymers 329 (2024)
ID 121782
|
/Variants 0/-+
|
-6)-a-D-Galp-(1-6)-a-D-Galp-(1-6)-b-D-Glcp-(1-6)-b-D-Glcp-(1-6)-b-D-Glcp-(1-
/Variants 0/ is:
a-D-Glcp-(1-2)-
OR (exclusively)
a-L-Fucp-(1-2)- |
Show graphically |
Hypsizygus marmoreus
(NCBI TaxID 39966,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
NCBI PubMed ID: 38286552Publication DOI: 10.1016/j.carbpol.2024.121782Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Yin JY <yinjy

ncu.edu.cn>; Nie SP <spnie

ncu.edu.cn>
Institutions: State Key Laboratory of Food Science and Resources, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, Nanchang, China, Food Laboratory of Zhongyuan, Henan, China
Glucans are the most abundant class of macromolecule polymers in fungi, which are commonly found in Ascomycota and Basidiomycota. Fungal glucans are not only essential for cell integrity and function but also crucial for the immense industrial interest in high value applications. They present a variety of structural characteristics at the nanoscale due to the high regulation of genes and the involvement of stochastic processes in synthesis. However, although recent findings have demonstrated the genes of glucans synthesis are relatively conserved across diverse fungi, the formation and organization of diverse glucan structures is still unclear in fungi. Here, we summarize the structural features of fungal glucans and the recent developments in the mechanisms of glucans biosynthesis. Furthermore, we propose the engineering strategies of targeted glucan synthesis and point out the remaining challenges in the synthetic process. Understanding the synthesis process of diverse glucans is necessary for tailoring high value glucan towards specific applications. This engineering strategy contributes to enable the sustainable and efficient production of glucan diversity
biosynthesis, gene, diversity, glucan, fungi, target glucan
Structure type: structural motif or average structure
Location inside paper: Fig. 1, fucogalactoglucan, structure 2
Compound class: polysaccharide, fucogalactoglucan
Contained glycoepitopes: IEDB_134624,IEDB_135614,IEDB_136045,IEDB_136906,IEDB_137472,IEDB_140529,IEDB_141794,IEDB_141806,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144998,IEDB_146664,IEDB_151528,IEDB_152214,IEDB_167069,IEDB_174333,IEDB_190606,IEDB_241101,IEDB_983931,SB_163,SB_192,SB_7,SB_86
Comments, role: review
NCBI Taxonomy refs (TaxIDs): 39966
Show glycosyltransferases
There is only one chemically distinct structure:
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