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Liu J, Sun Y
Structural analysis of an alkali-extractable and water-soluble polysaccharide (ABP-AW1) from the fruiting bodies of Agaricus blazei Murill
Carbohydrate Polymers 86(2) (2011)
429-432
|
/Variants 0/-+
|
-6)-{{{-/Variants 1/-}}}/n=4/-b-D-Glcp-(1-
/Variants 0/ is:
60%b-L-Fucp-(1-3)-
OR (exclusively)
20%b-L-Araf-(1-3)-
OR (exclusively)
20%D-Manp-(1-3)-
/Variants 1/ is:
b-D-Glcp-(1-6)-
OR (exclusively)
b-D-Galp-(1-6)- |
Show graphically |
Agaricus blazei
(NCBI TaxID 79798,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
The structure was elucidated in this paperPublication DOI: 10.1016/j.carbpol.2011.01.027Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Liu J <qyybliu
126.com>; Liu J <jichengliu
yahoo.cn>
Institutions: Pharmacochemistry & Biomacromolecule Research Laboratories, Qiqihar Medical University, Qiqihar, China
An alkali-extractable and water-soluble polysaccharide (ABP-AW1) was isolated by 5% sodium hydroxide solution from the fruiting body of Agaricus blazei. ABP-AW1 (Mw = 50 kDa), was composed of Gal, Glc, Fuc, Ara and Man with the molar ratio of 29: 20: 6: 2: 2. According to the combination of chemical and instrumental analysis, the results indicated that ABP-AW1 had a backbone consisting of (1→6)-linked-β-D-galactopyranosyl, (1→6)-linked-β-D-glucopyranosyl and (1→3, 6)-linked-β-D-glucopyranosyl, which was terminated with (1→)–linked Fuc, Ara and Man residues at the O-3 position of (1→3, 6)-linked-β-D-glucopyranosyl in the proportion of 29: 10: 10: 6: 2:2.
polysaccharide, structural elucidation, Agaricus blazei, alkali-extractable
Structure type: structural motif or average structure ; 50000
Location inside paper: p. 431, column 2, paragraph 1, ABP-AW1
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_130701,IEDB_135614,IEDB_136044,IEDB_137472,IEDB_137485,IEDB_141794,IEDB_141806,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144983,IEDB_146664,IEDB_152206,IEDB_152214,IEDB_153201,IEDB_156489,IEDB_156493,IEDB_156557,IEDB_190606,IEDB_241101,IEDB_983930,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_44,SB_67,SB_7,SB_72,SB_86,SB_88
Methods: methylation, periodate oxidation, IR, GC-MS, acid hydrolysis, GC, Smith degradation, HPSEC, UV, extraction, acetylation, methylation analysis, reduction, CC, dialysis, precipitation, phenol-sulfuric acid assay, evaporation, Sevag method, centrifugation, UV-VIS, Lowry method, TFA hydrolysis, precipitaiton, periodate oxidatiion
Comments, role: Gal/Glc in linear part is 3:1
Related record ID(s): 42450, 42453
NCBI Taxonomy refs (TaxIDs): 79798
Show glycosyltransferases
There is only one chemically distinct structure:
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Cui L, Sun Y, Xu H, Cong H, Liu J
A polysaccharide isolated from Agaricus blazei Murill (ABP-AW1) as a potential Th1 immunity-stimulating adjuvant
Oncology Letters 6(4) (2013)
1039-1044
|
/Variants 0/-+
|
-6)-b-D-Glcp-(1-6)-b-D-Galp-(1-6)-b-D-Galp-(1-6)-b-D-Galp-(1-6)-b-D-Glcp-(1-
/Variants 0/ is:
60%b-L-Fucp-(1-3)-
OR (exclusively)
20%b-L-Araf-(1-3)-
OR (exclusively)
20%D-Manp-(1-3)- |
Show graphically |
Agaricus blazei
(NCBI TaxID 79798,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
The structure was elucidated in this paperNCBI PubMed ID: 24137460Publication DOI: 10.3892/ol.2013.1484Journal NLM ID: 101531236Publisher: Athens: Spandidos Publications
Correspondence: Liu J <ljcqqhr
126.com>
Institutions: Department of Medicinal Chemistry and Biomacromolecules, Qiqihar Medical University, Qiqihar, China, Department of Medicine Research, The First Affliated Hospital, Qiqihar Medical University, Qiqihar, China, Heilongjiang University of Chinese Medicine, Harbin, China
In the present study, a low molecular weight polysaccharide, ABP-AW1, isolated from Agaricus blazei Murill was assessed for its potential adjuvant activity. ABP-AW1 is considered to create a 'depot' of antigen at a subcutaneous injection site. ICR mice were immunized with 100 μg ovalbumin (OVA) alone or with 100 μg OVA formulated in 0.9% saline containing 200 μg aluminum (alum) or ABP-AW1 (50, 100 and 200 μg) on days 1 and 15. Two weeks after the secondary immunization, splenocyte proliferation, the expression of surface markers, cytokine production and the OVA-specific antibody levels in the serum were determined. The OVA/ABP-AW1 vaccine, in comparison with OVA alone, markedly increased the proliferation of splenic lymphocytes and elicited greater antigen-specific CD4+ T cell activation, as determined by splenic CD4+CD69+ T cells and Th1 cytokine interferon (IFN)-γ release. The combination of ABP-AW1 and OVA also enhanced IgG2b antibody responses to OVA. In conclusion, these data indicated that ABP-AW1 significantly enhanced the humoral and cellular immune responses against OVA in the mice, suggesting that ABP-AW1 stimulated Th1-type immunity. We suggest that ABP-AW1 may serve as a new adjuvant.
polysaccharide, vaccine, immune, Agaricus blazei, Th1
Structure type: structural motif or average structure
Location inside paper: p. 1040, column 2, paragraph 1, ABP-AW1
Compound class: cell wall polysaccharide
Contained glycoepitopes: IEDB_130701,IEDB_136044,IEDB_137472,IEDB_137485,IEDB_141794,IEDB_141806,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_144983,IEDB_146664,IEDB_152206,IEDB_152214,IEDB_153201,IEDB_156489,IEDB_156493,IEDB_190606,IEDB_241101,IEDB_983930,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_44,SB_67,SB_7,SB_72,SB_86,SB_88
Methods: ELISA, GPC, extraction, DEAE, cytokine assay, CC, dialysis, centrifugation, filtration, splenocyte proliferation assay, precipitaiton
Biological activity: ABP-AW1 is a candidate immunity-stimulating adjuvant, particulary promotes the development of Th1 polarization
Related record ID(s): 42450, 42452
NCBI Taxonomy refs (TaxIDs): 79798
Show glycosyltransferases
There is only one chemically distinct structure:
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Liu J, Sun Y
Structural analysis of an alkali-extractable and water-soluble polysaccharide (ABP-AW1) from the fruiting bodies of Agaricus blazei Murill
Carbohydrate Polymers 86(2) (2011)
429-432
|
/Variants 0/-+
|
-6)-b-D-Galp-(1-6)-b-D-Glcp-(1-
/Variants 0/ is:
30%b-L-Fucp-(1-3)-
OR (exclusively)
10%b-L-Araf-(1-3)-
OR (exclusively)
10%b-D-Glcp-(1-3)- |
Show graphically |
Agaricus blazei
(NCBI TaxID 79798,
species name lookup)
Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
The structure was elucidated in this paperPublication DOI: 10.1016/j.carbpol.2011.01.027Journal NLM ID: 8307156Publisher: Elsevier
Correspondence: Liu J <qyybliu
126.com>; Liu J <jichengliu
yahoo.cn>
Institutions: Pharmacochemistry & Biomacromolecule Research Laboratories, Qiqihar Medical University, Qiqihar, China
An alkali-extractable and water-soluble polysaccharide (ABP-AW1) was isolated by 5% sodium hydroxide solution from the fruiting body of Agaricus blazei. ABP-AW1 (Mw = 50 kDa), was composed of Gal, Glc, Fuc, Ara and Man with the molar ratio of 29: 20: 6: 2: 2. According to the combination of chemical and instrumental analysis, the results indicated that ABP-AW1 had a backbone consisting of (1→6)-linked-β-D-galactopyranosyl, (1→6)-linked-β-D-glucopyranosyl and (1→3, 6)-linked-β-D-glucopyranosyl, which was terminated with (1→)–linked Fuc, Ara and Man residues at the O-3 position of (1→3, 6)-linked-β-D-glucopyranosyl in the proportion of 29: 10: 10: 6: 2:2.
polysaccharide, structural elucidation, Agaricus blazei, alkali-extractable
Structure type: structural motif or average structure ; 50000
Location inside paper: Table 1
Compound class: polysaccharide
Contained glycoepitopes: IEDB_136044,IEDB_137472,IEDB_141794,IEDB_142488,IEDB_142489,IEDB_144562,IEDB_146664,IEDB_152214,IEDB_153543,IEDB_190606,IEDB_983931,SB_165,SB_166,SB_187,SB_192,SB_195,SB_7,SB_86,SB_88
Methods: methylation, periodate oxidation, IR, GC-MS, acid hydrolysis, GC, Smith degradation, HPSEC, UV, extraction, acetylation, methylation analysis, reduction, CC, dialysis, precipitation, phenol-sulfuric acid assay, evaporation, Sevag method, centrifugation, UV-VIS, Lowry method, TFA hydrolysis, precipitaiton, periodate oxidatiion
NCBI Taxonomy refs (TaxIDs): 79798
Show glycosyltransferases
There is only one chemically distinct structure:
Expand this record
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