CSDB: Search results

Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)

NCBI PubMed ID: 26932183
Publication DOI: 10.3852/15-312
Journal NLM ID: 0400764
Publisher: Abingdon, Oxon, UK: Taylor & Francis
Correspondence: Fontaine T <thierry.fontaine

pasteur.fr>
Institutions: Unité des Aspergillus, Institut Pasteur, Paris

Galactosaminogalactan (GAG) is an extracellular polysaccharide produced by the mycelium of the opportunistic human fungal pathogen Aspergillus fumigatus GAG is the first polysaccharide described as a virulence factor in medical mycology. This review presents our current knowledge of the structural organization and biosynthesis of this polymer. The function of this molecule as an adhesin that also masks Aspergillus PAMPs and the impact of GAG on the modulation of the host immune response by inducing neutropenia and blocking the IL-1 signaling pathway also will be emphasised.

virulence factor, Aspergillus fumigatus, galactosaminogalactan, IL-1Ra, neutrophil apoptosis

Structure type: structural motif or average structure
Location inside paper: galactosaminogalactan, GAG, in text, p. 572
Compound class: galactosaminogalactan
Contained glycoepitopes: IEDB_130648,IEDB_136906,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_141584,IEDB_141794,IEDB_144989,IEDB_151528,IEDB_190606,IEDB_885822,SB_7

Biosynthesis and genetic data: biochemical data
Comments, role: schematic representation of A. fumigatus galactosaminogalactan structure

Related record ID(s): 42924
NCBI Taxonomy refs (TaxIDs): 746128
Reference(s) to other database(s): GTC:G53212DW
Show glycosyltransferases

There are too many chemically distinct structures (~1024), so only one is shown:

aDGalp(1-4)[%Ac(1-2)]aDGalpN(1-4)[%Ac(1-2)]aDGalpN(1-4)aDGalp(1-4)[%Ac(1-2)]aDGalpN(1-4)aDGalp(1-4)[%Ac(1-2)]aDGalpN(1-4)aDGalp(1-4)aDGalpN(1-4)[%Ac(1-2)]aDGalpN

CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O[C@H]2O[C@H](CO)[C@H](O[C@H]3O[C@H](CO)[C@H](O[C@H]4O[C@H](CO)[C@H](O[C@H]5O[C@H](CO)[C@H](O[C@H]6O[C@H](CO)[C@H](O[C@H]7O[C@H](CO)[C@H](O[C@H]8O[C@H](CO)[C@H](O[C@H]9O[C@H](CO)[C@H](O[C@H]%10O[C@H](CO)[C@H](O)[C@H](O)[C@H]%10O)[C@H](O)[C@H]9NC(C)=O)[C@H](O)[C@H]8NC(C)=O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6NC(C)=O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4NC(C)=O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2N)[C@@H]1O

SVG MW SMILES 3D mol Ionize

Warning = sub-repeat ending at a?GalpN: variable unit count (1-10) was assumed to be 1
Warning = sub-repeat ending at a?Galp: unknown unit count was assumed to be 3
Warning = sub-repeat ending at a?GalpN: variable unit count (1-10) was assumed to be 1

Aspergillus fumigatus

(previously named: Sartorya fumigata, Aspergillus fumigates, Neosartorya fumigata)
(NCBI TaxID 746128, species name lookup)

Taxonomic group: fungi / Ascomycota (Phylum: Ascomycota)
Associated disease: infection due to Aspergillus fumigatus [ICD11: XN5Z7

]

Publication DOI: 10.1070/RCR4750
Journal NLM ID: 0404506
Publisher: London: Chemical Society
Correspondence: Nifantiev NE <nen

ioc.ac.ru>
Institutions: N.D.Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

The cell wall of opportunistic pathogenic yeast fungi Candida and mould fungi Aspergillus is highly important for the pathogenesis of fungal infections, as it is the first to interact with the cells of the host organism, is responsible for pathogen adhesion and intra- and intercellular communications and bears important antigenic determinants. Fungal cell walls are composed mainly of polysaccharides. Methods that are currently used to study biological functions of cell wall polysaccharides require samples that are structurally characterized and have sufficient homogeneity and purity. However, the isolation of such samples from fungal cultures is often poorly feasible. Therefore, synthetic oligosaccharides of strictly specified structure corresponding to polysaccharide fragments of the cell wall of pathogenic fungi are indispensable tools for investigating the biological functions of such compounds. The review surveys studies devoted to the synthesis of oligosaccharides corresponding to fragments of major polysaccharide components of the fungal cell wall of Candida and Aspergillus: mannan, α- and β-(1→3)-glucans, chitin, galactosaminogalactan and galactomannan.

Structure type: structural motif or average structure
Location inside paper: p. 1075 (bottom of the page), galactosaminogalactan
Compound class: galactosaminogalactan
Contained glycoepitopes: IEDB_130648,IEDB_136906,IEDB_137472,IEDB_137473,IEDB_1391961,IEDB_141584,IEDB_141794,IEDB_144989,IEDB_151528,IEDB_190606,IEDB_885822,SB_7

Comments, role: schematic representation of A. fumigatus galactosaminogalactan structure

Related record ID(s): 42858, 42925, 42926, 42927
NCBI Taxonomy refs (TaxIDs): 746128
Reference(s) to other database(s): GTC:G53212DW
Show glycosyltransferases

There are too many chemically distinct structures (~1024), so only one is shown:

aDGalp(1-4)[%Ac(1-2)]aDGalpN(1-4)[%Ac(1-2)]aDGalpN(1-4)aDGalp(1-4)[%Ac(1-2)]aDGalpN(1-4)aDGalp(1-4)[%Ac(1-2)]aDGalpN(1-4)aDGalp(1-4)aDGalpN(1-4)[%Ac(1-2)]aDGalpN

SVG MW SMILES 3D mol Ionize