Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: capsuleAssociated disease: infection due to Cryptococcus gattii [ICD11:
XN0LE 
]
The structure was elucidated in this paperNCBI PubMed ID: 6772300Publication DOI: 10.1016/S0008-6215(00)85524-XJournal NLM ID: 0043535Publisher: Elsevier
Institutions: National Institute of Arthritis, Metabolism, and Digestive Diseases and Kidney, National Institutes of Health, Bethesda, USA, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA
The capsular material from Cryptococcus bacillisporus serotype B has been separated into essentially two fractions. One of these (60% of the total) has been studied by the methods usual for the structural elucidation of polysaccharides. The results are consistent with a structure having nonreducing D-xylosyl as well as D-glucosyluronic acid groups attached to O-2 of D-mannosyl residues linked α-(1→3) in a linear backbone. Every third D-mannosyl residue is doubly substituted with a D-xylosyl group at O-2 and a D-glucosyluronic acid group at O-4.
carbohydrates, immunology, Bacterial polysaccharide, serotyping, cryptococcosis, cryptococcus bacillisporus
Structure type: suggested polymer biological repeating unit
Location inside paper: p.109
Trivial name: glucuronoxylomannan (GXM), glucuronoxylomannan
Compound class: EPS, O-polysaccharide, O-antigen, CPS, cell wall polysaccharide, polysaccharide, glucuronoxylomannan, capsule polysaccharide
Contained glycoepitopes: IEDB_114701,IEDB_115136,IEDB_115576,IEDB_130701,IEDB_140116,IEDB_140630,IEDB_144983,IEDB_145668,IEDB_152206,IEDB_164174,IEDB_167188,IEDB_174332,IEDB_423153,IEDB_76933,IEDB_983930,SB_197,SB_44,SB_67,SB_72
Methods: 1H NMR, methylation, GLC-MS, acid hydrolysis, GLC, alkaline degradation, Smith degradation, paper chromatography, ion-exchange chromatography, quantification of O-acetylation, immunodiffusion assays, periodate oxidation, optical rotation measurement, autohydrolysis, oxidation with chromium trioxide, reduction, column chromatography, gel permeation chromatography, phenol-sulfuric acid assay, evaporation, immunoelectrophoresis
Comments, role: chemical repeating unit frame was shifted in annotation for compatibility with structures elucidated by MS [Eukaryotic Cell 2007, 6: 1464-1473]; approx. 10,4% O-acetyl groups
Related record ID(s): 40816, 42130, 43808, 43816, 43822, 43917, 44110, 44281, 44283, 44286, 44351
NCBI Taxonomy refs (TaxIDs): 552467Reference(s) to other database(s): GTC:G42955PN
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Cryptococcus gattii VGIII B 444)