Taxonomic group: bacteria / Proteobacteria
(Phylum: Proteobacteria)
NCBI PubMed ID: 3830434Publication DOI: 10.1248/cpb.33.5096Journal NLM ID: 0377775Publisher: Pharmaceutical Society Of Japan
Institutions: Tokyo College of Pharmacy, Tokyo, Japan
An antitumor β-1,3-glucan (PVG) was purified from PVA-S by sequential use of a-amylase digestion, ethanol precipitation, ion exchange chromatography on diethyl aminoethyl Sephadex A-25, ammonium sulfate fractionation, and GPC on Sepharose CL-2B. PVG showed [α]D + 28.4° (water). From the results of methylation analysis and carbon 13 nuclear magnetic resonance spectroscopy, PVG is a β-1,3-glucan branched at position 6 of every fifth 3-substituted β-glucosyl unit. PVG formed a complex with Congo Red in neutral and dilute alkali solution, but this complex was dissociated at more than 0.2N NaOH. PVG showed potent antitumor activity against the solid form of sarcoma 180 tumor in ICR mice.
polysaccharide, β-1, antitumor agent, Peziza vesiculosa, vesiculogen, 3-glucan, sarcoma 180
Structure type: homopolymer
Location inside paper: p.5098, paragraph 3, fig.2
Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, callose, laminarin, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, cell wall glucan, polysaccharide, glycoside, β-glucan, β-1, 3-glucan
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: 13C NMR, methylation, GPC, enzymatic digestion, ion-exchange chromatography, extraction, optical rotation measurement, column chromatography, ethanol precipitation, antitumor activity assay, complex formation with Congo Red
Related record ID(s): 27206, 43967, 43969
NCBI Taxonomy refs (TaxIDs): 511Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:
157, CCSD:
50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
Show glycosyltransferases
NMR conditions: in DMSO-d6 at 333(C) K
[as TSV]
13C NMR data: present in publication
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There is only one chemically distinct structure:
Found 
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