Cortés-Sánchez AJ, Hernández-Sánchez H, Jaramillo-Flores ME Biological activity of glycolipids produced by microorganisms: New trends and possible therapeutic alternatives Microbiological Research168(1) (2013)
22-32
/Variants 0/-+
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3HOOco-(1-2)-b-D-Glcp-(1-4)-b-D-Glcp6Ac
/Variants 0/ is:
2,15,16HOPam-(16-1)-
OR (exclusively)
15,16HOPam-(16-1)-
NCBI PubMed ID:22959834 Publication DOI:10.1016/j.micres.2012.07.002 Journal NLM ID:9437794 Publisher: G. Fischer Correspondence: jaramillo_floreshotmail.com Institutions: Departamento de Graduados e Investigación en Alimentos, Escuela Nacional de Ciencias Biológicas-IPN, Carpio y Plan de Ayala, México, Mexico
Several biological processes in prokaryotic and eukaryotic organisms require the presence of glycolipids (biosurfactants), compounds with both hydrophilic and hydrophobic groups in their structure. They constitute the backbone of different metabolic functions and biological structures such as cell membranes. Besides being structural components, glycolipids show surface activity in the interfaces and are mainly produced by microorganisms. Interest in biosurfactants has increased considerably in recent times due to their applications in the environmental, oil, food, and pharmaceutical industries, since they have unique properties such as low toxicity, high biodegradability, environmentally friendly, foaming capacity, high selectivity and specificity at extreme temperatures, pH and salinity, as well as biological activity. All of these properties are considered advantages over other chemical surfactants, and therefore glycolipids are considered a good alternative, given the current interest on sustainable development. The present work shows a general view of bio-surfactants of microbial origin, particularly of glycolipids, referring to several studies on their biological activity that have revealed their great potential in the medical–biological field, discovering interesting possibilities for their therapeutic application in the near future.
Biological activity: antimicrobial activity Enzymes that release or process the structure: Emt1, Mac 1, Mac 2, Mat 1 Comments, role: review; acyl chain in 3HOOco can be shorter; authors do not provide its length
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