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Taxonomic group: fungi / Basidiomycota (Phylum: Basidiomycota)
Organ / tissue: fruiting body

NCBI PubMed ID: 2711382
Publication DOI: 10.1620/tjem.157.145
Journal NLM ID: 0417355
Publisher: Sendai: Tohoku University Medical Library
Institutions: Third Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan

A conventional limulus test detects not only endotoxin but also β-(1-3)-glucan. Therefore, using a quantitative limulus test (the limulus colorimetric test) we studied the pharmacokinetics of lentinan, an antitumor β-(1-3)-glucan, in the blood of 10 health volunteers and three patients with advanced gastric cancer. The calibration curve of lentinan in the human plasma was linear in the range of 0 to 100 ng/ml. When incubated with human plasma at 37 degrees C in vitro, lentinan had the recovery of almost 100% as compared to the initial concentration even after 60-min incubation, indicating the stability of lentinan in human plasma. When 1 mg of lentinan was intravenously administered over a 2 hr period, lentinan concentration reached the maximum levels (50-80 ng/ml) at the end of the drip infusion and decreased gradually thereafter. In the near future, the more appropriate modes of lentinan administration will be determined by further investigation of its kinetics in the human body.

lentinan, limulus test, gastric cancer, β-(1-3)-glucan

Structure type: structural motif or average structure
Location inside paper: lentinan, p.145
Trivial name: lentinan
Compound class: O-polysaccharide, glucan, polysaccharide, β-glucan
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192

Methods: colorimetric assays, biological assay, limulus colorimetric test
Comments, role: calibration curve of lentinan in the human plasma was linear in the range of 0 to 100 ng/ml

Related record ID(s): 45377, 45378, 45379, 45380, 45383, 45384, 45385, 45387, 45388, 45389, 45390, 45391, 45392, 45393, 45394, 45395, 45396, 45397, 45398, 45399, 45405, 45408, 48347, 48358, 48474, 48490, 49209
NCBI Taxonomy refs (TaxIDs): 5353
Reference(s) to other database(s): GTC:G14698DR
Show glycosyltransferases

There is only one chemically distinct structure:

[*]O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](O[C@@H]4[C@@H](O)[C@H](O[C@@H]5[C@@H](O)[C@H]([*])O[C@H](CO)[C@H]5O)O[C@H](CO[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H]4O)O[C@H](CO)[C@H]3O)O[C@H](CO[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@H]2O)[C@@H]1O

SVG MW SMILES 3D mol Ionize