Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 6982258Publication DOI: 10.1016/0162-3109(82)90037-6Journal NLM ID: 7902474Publisher: Amsterdam: Elsevier/North-Holland
Institutions: Laboratory of Immunodiagnosis, National Cancer Institute, Bethesda, Maryland, USA, Department of Pharmacology, Rush University, Chicago, IL, USA, Deputy-Director, Institute for Clinical Immunology, University of Bern Medical Center, Bern, Switzerland, Biological Development Branch, Biological Response Modifiers Program, National Cancer Institute Frederick Cancer Research Facility, Frederick, USA
Activated human monocytes produce a monokine, interleukin-1 (IL-1) which can amplify the immune response by inducing antigen specific T cells to elaborate T cell growth factor, or interleukin-2, which in turn causes T cells to proliferate. The immune adjuvant lentinan has been shown in this study to augment IL-1 production by human monocytes. Stimulation of IL-1 by lentinan was seen as early as 5 hr, with some effect as late as 60 hr. Optimal effects were seen with very low concentrations, around 0.1 μg/ml. Lentinan was also able to stimulate IL-1 production by the leukemic cell line, K-562. The data reported here suggest that the previously reported adjuvant effects of lentinan may in part be mediated via its ability to stimulate IL-1 production.
macrophages, Monocytes, Immunotherapy, lentinan, Immunoadjuvants, lymphocyte proliferation, accessory cells, chronic myeloid leukemia, interleukin-1, K-562 cell line, phorbol myristate acetate
Structure type: structural motif or average structure
Location inside paper: lentinan, p.66
Trivial name: lentinan
Compound class: O-polysaccharide, glucan, polysaccharide, β-glucan
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: interleukin-1 assay, biological assay, antitumor activity assay, monocyte stimulation
Biological activity: stimulated release of IL-I, with maximal stimulation at a dose of 0.01 μg/ml giving thymocyte proliferation more than 4 times above the medium control; Monocytes treated with lentinan, phytohemagglutinin or combinations of lentinan with phytohemagglutinin, produced the greatest IL-1 activity at 5 h, followed by declining levels of activity; stimulated some low level production of IL-I by K-562 cells, with 5 μg/ml being the most effective dose
Related record ID(s): 45376, 45377, 45379, 45380, 45383, 45384, 45385, 45387, 45388, 45389, 45390, 45391, 45392, 45393, 45394, 45395, 45396, 45397, 45398, 45399, 45405, 45408, 48347, 48358, 48474, 48490, 49209
NCBI Taxonomy refs (TaxIDs): 5353Reference(s) to other database(s): GTC:G14698DR
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Lentinula edodes)