Taxonomic group: fungi / Basidiomycota
(Phylum: Basidiomycota)
Organ / tissue: fruiting body
NCBI PubMed ID: 4597986Publication DOI: 10.1002/ijc.2910110118Journal NLM ID: 42124Publisher: New York, NY: Wiley-Liss
Institutions: National Cancer Center Research Institute, Tokyo, Japan
The mechanism of antitumour action of the polysaccharides, lentinan and carboxymethylpachymaran, was examined and compared with that of zymosan. It was revealed that (1) these polysaccharides did not show any direct cytocidal effect on tumour cells; (2) these polysaccharides had no antitumour action at all in neonatally thymectomized mice, indicating the important role of the thymus gland in tumour regression; and (3) in spite of these facts, these polysaccharides, contrary to zymosan, did not accelerate various conventional immune responses such as phagocytic activity, antibody production against heterologous antigen, increased number of peripheral lymphocytes, skin homograft rejection, and delayed hypersensitivity. This evidence suggests the presence of a complex and unknown mechanism for regression of transplanted tumour in the action of lentinan and carboxymethylpachymaran.
antitumor activity, neonatal thymectomy
Structure type: structural motif or average structure ; 1000000
Location inside paper: lentinan, p.153
Trivial name: lentinan
Compound class: glucan
Contained glycoepitopes: IEDB_1397514,IEDB_141806,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_241101,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: biological assay, antitumor activity assay, neonatal thymectomy
Biological activity: Antitumour activity is very strong in normal mice and 99.2% tumour inhibition ratio was obtained with a dose of 1 mg/kg x 10, and complete regression of tumour was observed in 9 out of 10 mice; in the case of neonatally thymectomized mice, tumour inhibition ratio of lentinan was only 6.4% and there was no complete regression of the tumour
Related record ID(s): 45376, 45377, 45378, 45379, 45380, 45383, 45384, 45386, 45387, 45388, 45389, 45390, 45391, 45392, 45393, 45394, 45395, 45396, 45397, 45398, 45399, 45405, 45408, 48347, 48358, 48474, 48490, 49209
NCBI Taxonomy refs (TaxIDs): 5353Reference(s) to other database(s): GTC:G14698DR
Show glycosyltransferases
There is only one chemically distinct structure:
Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
NCBI PubMed ID: 4597986Publication DOI: 10.1002/ijc.2910110118Journal NLM ID: 42124Publisher: New York, NY: Wiley-Liss
Institutions: National Cancer Center Research Institute, Tokyo, Japan
The mechanism of antitumour action of the polysaccharides, lentinan and carboxymethylpachymaran, was examined and compared with that of zymosan. It was revealed that (1) these polysaccharides did not show any direct cytocidal effect on tumour cells; (2) these polysaccharides had no antitumour action at all in neonatally thymectomized mice, indicating the important role of the thymus gland in tumour regression; and (3) in spite of these facts, these polysaccharides, contrary to zymosan, did not accelerate various conventional immune responses such as phagocytic activity, antibody production against heterologous antigen, increased number of peripheral lymphocytes, skin homograft rejection, and delayed hypersensitivity. This evidence suggests the presence of a complex and unknown mechanism for regression of transplanted tumour in the action of lentinan and carboxymethylpachymaran.
antitumor activity, neonatal thymectomy
Structure type: homopolymer
Location inside paper: p.154, zymosan
Trivial name: glucan, β-1,3-glucan, curdlan, curdlan-type polysaccharide 13140, paramylon, curdlan, laminarin, β-glucan, curdlan, β-(1,3)-glucan, β-(1,3)-glucan, curdlan, curdlan, β-1,3-glucan, paramylon, reserve polysaccharide, b-glucan, β-1,3-D-glucan, laminaran, botryosphaeran, laminaran type β-D-glucan, latiglucan I, pachymaran, Curdlan, zymosan A, β-glucan, curdlan, laminarin, zymosan, zymosan, glucan particles, zymosan, β-(1-3)-glucan, β-(1,3)-glucan, β-(1,3)glucan, pachymaran, D-glucan (DPn)540, pachyman, laminaran, curdlan, zymosan, zymosan, β-(1,3)-glucan, zymosan A, zymosan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, β-1,3-glucan, curdlan, pachyman, β-(1,3)-glucan, curdlan, callose, a water-insoluble β-(1→3)-glucan, fermentum β-polysaccharide, water-insoluble glucan, callose, laminarin, alkali-soluble β-glucan (PeA3), alkali-soluble polysaccharide (PCAP)
Compound class: EPS, O-polysaccharide, cell wall polysaccharide, lipophosphoglycan, glycoprotein, LPG, glucan, cell wall glucan, polysaccharide, glycoside, β-glucan, β-1, 3-glucan
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: biological assay, antitumor activity assay, neonatal thymectomy
Biological activity: tumour inhibition ratio being 43.0% at 25 mgfkgx 10 and 71.9-83.9% at 5 mg/kgx10 in our assay system; zymosan showed no antitumour effect in neonatally thymectomized mice
Related record ID(s): 45385
NCBI Taxonomy refs (TaxIDs): 4932Reference(s) to other database(s): GTC:G51056AN, GlycomeDB:
157, CCSD:
50049, CBank-STR:4225, CA-RN: 51052-65-4, GenDB:FJ3380871.1
Show glycosyltransferases
There is only one chemically distinct structure:
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(later renamed to: Lentinula edodes)