Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: cell wall
NCBI PubMed ID: 22728440Publication DOI: 10.2183/pjab.88.250Journal NLM ID: 9318162Publisher: Japan Academy
Correspondence: suzusige
seagreen.ocn.ne.jp
Institutions: Sendai Research Institute for Mycology, Miyagi, Japan, Department of Infection and Host Defense, Tohoku Pharmaceutical University, Miyagi, Japan, Department of Microbiology, Nagasaki International University, Nagasaki, Japan, Tohoku Pharmaceutical University, Miyagi, Japan
This review describes recent findings based on structural and immunochemical analyses of the cell wall mannan of Candida albicans, and other medically important Candida species. Mannan has been shown to consist of α-1,2-, α-1,3-, α-1,6-, and β-1,2-linked mannopyranose units with few phosphate groups. Each Candida species has a unique mannan structure biosynthesized by sequential collaboration between species-specific mannosyltransferases. In particular, the β-1,2-linked mannose units have been shown to comprise a characteristic oligomannosyl side chain that is strongly antigenic. For these pathogenic Candida species, cell-surface mannan was also found to participate in the adhesion to the epithelial cells, recognition by innate immune receptors and development of pathogenicity. Therefore, clarification of the precise chemical structure of Candida mannan is indispensable for understanding the mechanism of pathogenicity, and for development of new antifungal drugs and immunotherapeutic procedures.
pathogenicity, mannan, 1H NMR, Candida, Mannosyltransferase, Dectin-2
Structure type: fragment of a bigger structure
Location inside paper: Fig.1, top structure
Aglycon: protein
Compound class: glycopeptide
Contained glycoepitopes: IEDB_135813,IEDB_137340,IEDB_141807,IEDB_151531
Related record ID(s): 45761, 45762, 45763, 45764, 45765, 45766, 45767, 45768, 45769, 45770
NCBI Taxonomy refs (TaxIDs): 4932,
5476,
4929,
36911,
5478
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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