Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
The structure was elucidated in this paperNCBI PubMed ID: 26434299Publication DOI: 10.1016/j.foodchem.2011.10.087Journal NLM ID: 7702639Publisher: Elsevier Applied Science Publishers
Correspondence: Ye M <yeming123
sina.com>
Institutions: College of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, China, Department of Biological and Environmental Engineering, Hefei University, Hefei, China
A homogeneous extracellular polysaccharide of Lachnum YM261 (LEPS-1) with a molecular weight of 21670Da was characterised. According to HPGPC, IR, periodate oxidation and Smith degradation, GC-MS and 1H NMR analysis, the results indicated that LEPS-1 was a glucan linked by the β-(1→3)-D-pyran glycosidic bond. The effect of LEPS-1 on anti-ageing in d-gal model mice was also studied. It was found that LEPS-1 significantly increased the activities of antioxidant enzymes (i.e. SOD superoxide dismutase, CAT catalase, GSH-PX glutathione peroxidase) and decreased malondialdehyde (MDA) content in liver, brain and serum of d-gal model mice. These results showed that LEPS-1 had a strong anti-ageing activity.
exopolysaccharide, purification, β-(1→3)-d-Glucan, anti-ageing activity, Lachnum
Structure type: homopolymer ; 21670
Location inside paper: Fig.4, LEPS-1
Trivial name: β-(1,3)-glucan
Compound class: O-polysaccharide, glucan
Contained glycoepitopes: IEDB_1397514,IEDB_142488,IEDB_146664,IEDB_153543,IEDB_158555,IEDB_161166,IEDB_558869,IEDB_857743,IEDB_983931,SB_192
Methods: 1H NMR, IR, GC-MS, acid hydrolysis, Smith degradation, biological assays, UV, extraction, periodate oxidation, acetylation, reduction, column chromatography, cell growth, HPGPC, precipitation, Sevag method
Biological activity: LEPS-1 can significantly increase the food intake, weight gain rate and the antioxidase activity in the body of aged mice, and can inhibit the formation of lipid peroxidation products and slow down the ageing process.
NCBI Taxonomy refs (TaxIDs): 47817Reference(s) to other database(s): GTC:G51056AN
Show glycosyltransferases
NMR conditions: in D2O / DSS at 333(H) K
[as TSV]
1H NMR data: present in publication
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There is only one chemically distinct structure:
Found 
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