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1. (Article ID: 4618)
Silipo A, Di Lorenzo F, Fazio LL, Paciello I, Sturiale L, Palmigiano A, Parrilli M, Grant WD, Garozzo D, Lanzetta R, Bernardini ML, Molinaro A
Structure and immunological activity of the lipopolysaccharide isolated from the species Alkalimonas delamerensis
European Journal of Organic Chemistry (13) (2013)
2653-2665
We have defined the complete structure and assessed the biological activity of the lipopolysaccharide (LPS) from Alkalimonas delamerensis, an alkaliphilic bacterium isolated from soda lakes in China and East Africa. The structural determination, which was achieved by the use of chemical, spectroscopic and spectrometric approaches, indicates a novel Rough type lipopolysaccharide that is rich in negatively charged groups in the lipid A inner core region. The proinflammatory activity of the pure lipopolysaccharide has also been defined by testing the LPS as a stimulant in human HEK293 cells, which express the CD14/MD2/TLR4 complex (HEK293-hTLR4), and in bone marrow-derived macrophages.
carbohydrates, Oligosaccharides, inflammation, natural products, medicinal chemistry, structureactivity relationships
Publication DOI: 10.1002/ejoc.201201702Journal NLM ID: 9805750Publisher: Wiley-VCH
Correspondence: silipo
unina.it
Institutions: Dipartimento di Scienze Chimiche, Universita di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy, Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza-Università di Roma, Via Dei Sardi, 70, 00185 Roma, Italy, Istituto di Chimica e Tecnologia dei Polimeri - ICTP - CNR, Via P. Gaifami 18, 95126 Catania, Italy, Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom, Isituto Pasteur-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185 Roma, Italy
Methods: 13C NMR, 1H NMR, GLC-MS, NMR-2D, 31P NMR, deacylation, acid hydrolysis, GLC, MALDI-TOF MS, composition analysis, NMR-1D
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2. (Article ID: 4619)
Silipo A, Di Lorenzo F, Fazio LL, Paciello I, Sturiale L, Palmigiano A, Parrilli M, Grant WD, Garozzo D, Lanzetta R, Bernardini ML, Molinaro A
Structure and immunological activity of the lipopolysaccharide isolated from the species Alkalimonas delamerensis
European Journal of Organic Chemistry 2013(13) (2013)
2653-2665
We have defined the complete structure and assessed the biological activity of the lipopolysaccharide (LPS) from Alkalimonas delamerensis, an alkaliphilic bacterium isolated from soda lakes in China and East Africa. The structural determination, which was achieved by the use of chemical, spectroscopic and spectrometric approaches, indicates a novel Rough type lipopolysaccharide that is rich in negatively charged groups in the lipid A inner core region. The proinflammatory activity of the pure lipopolysaccharide has also been defined by testing the LPS as a stimulant in human HEK293 cells, which express the CD14/MD2/TLR4 complex (HEK293-hTLR4), and in bone marrow-derived macrophages.
carbohydrates, Oligosaccharides, inflammation, natural products, medicinal chemistry, structureactivity relationships
Publication DOI: 10.1002/ejoc.201201702Journal NLM ID: 9805750Publisher: Wiley-VCH
Correspondence: silipo
unina.it (A. Silipo)
Institutions: Dipartimento di Scienze Chimiche, Universita di Napoli Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy, Dipartimento di Biologia e Biotecnologie “Charles Darwin”, Sapienza-Università di Roma, Via Dei Sardi, 70, 00185 Roma, Italy, Istituto di Chimica e Tecnologia dei Polimeri - ICTP - CNR, Via P. Gaifami 18, 95126 Catania, Italy, Department of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE1 9HN, United Kingdom, Isituto Pasteur-Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185 Roma, Italy
Methods: 13C NMR, 1H NMR, GLC-MS, NMR-2D, 31P NMR, deacylation, acid hydrolysis, GLC, MALDI-TOF MS, composition analysis, NMR-1D
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