Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
The structure was elucidated in this paperNCBI PubMed ID: 24273867Journal NLM ID: 101477873Publisher: Natural Product Communications
Correspondence: cutler
olemiss.edu
Institutions: Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, Oxford, USA, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, USA, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
A new polyketide derivative koninginin H (1), has been isolated from the fungus Emericella nidulans, together with koninginin E (2), koninginin A (3), trichodermatide B (4), citrantifidiol (5), (4S,5R)-4-hydroxy-5-methylfuran-2-one (6), the glycerol derivatives gingerglycolipid B (7), (2S)-bis[9Z,12Z]-1-O, 2-O-dilinoleoyl-3-O-[α-D-galactopyranosyl-(1"→6') β-D-galactopyranosyl]glycerol (8), (2S)-bis[9Z,12Z]-1-O, 2-O-dilinoleoyl-3-O-β-D-galactopyranosylglycerol (9), the cerebroside flavuside B (10), and the known sterols β-sitosterol glucoside and ergosta-5,7,22-trien-3-ol. Their structures were established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC) and mass spectrometry. The antibacterial, antimalarial, antifungal and antileishmanial activities of compounds 1-10 were examined and the results indicated that compound 4 showed good antifungal activity against Cryptococcus neoformans with an IC50 value of 4.9 microg/mL.
cerebroside, Emericella nidulans, koninginin, galactolipids
Structure type: monomer
Location inside paper: fig.1, compound 9
Compound class: glycolipid
Contained glycoepitopes: IEDB_136044,IEDB_137472,IEDB_141794,IEDB_190606,SB_165,SB_166,SB_187,SB_195,SB_7,SB_88
Methods: 13C NMR, 1H NMR, NMR-2D, GC-MS, TLC, GC, HPLC, UV, extraction, optical rotation measurement, CC, antimicrobial assay, antimalarial assays, antileishmanial assays
Related record ID(s): 47108, 47109, 47111
NCBI Taxonomy refs (TaxIDs): 162425
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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