Taxonomic group: fungi / Ascomycota
(Phylum: Ascomycota)
Organ / tissue: thallus
The structure was elucidated in this paperNCBI PubMed ID: 14764094Publication DOI: 10.1111/j.1432-1033.2004.03981.xJournal NLM ID: 0107600Publisher: Oxford, UK: Blackwell Science Ltd. on behalf of the Federation of European Biochemical Societies
Correspondence: Srebnik M <msrebni
md.huji.ac.il>
Institutions: Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel, Teva Pharmaceutical Industries Ltd, Petach Tikva, Israel, Division of Environment Science, The Fredy and Nadine Herrmann Graduate School of Applied Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel, Department of Dermatology, Hadassah University Hospital, Jerusalem, Israel, Institute of Ecology, Haifa University, Haifa, Israel
A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.
mycosporine, lichenized ascomycete, Collema cristatum, photo protective activity, UV-B
Structure type: monomer ; 497 [M+H]+
C
19H
32N
2O
13Location inside paper: fig.1
Trivial name: collemin A
Compound class: mycosporine
Contained glycoepitopes: IEDB_142488,IEDB_144998,IEDB_146664,IEDB_983931,SB_192
Methods: 13C NMR, 1H NMR, NMR-2D, IR, HPLC, UV, extraction, biological assay, HR-FAB-MS, UVB irradiation
Biological activity: the pure compound was applied to the inside forearm of a volunteer 30 min prior to four minimal erythema dose of UV-B irradiation, the isolated compound totally prevented UV-B induced erythema
Comments, role: mycobiont was also isolated from thallus; symbiotic organism
Related record ID(s): 48023
NCBI Taxonomy refs (TaxIDs): 402075
Show glycosyltransferases
There is only one chemically distinct structure:
Found 
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